ITD 1
| 中文名稱 | ITD 1 |
|---|---|
| 中文同義詞 | 4-[1,1'-聯(lián)苯]-4-基-1,4,5,6,7,8-六氫-2,7,7-三甲基-5-氧代-3-喹啉羧酸乙酯;4-([1,1'-聯(lián)苯]-4-基)-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氫喹啉-3-羧酸乙酯;化合物ITD1;ITD 1 (TGF-Β RECEPTOR抑制劑);4-([1,1'-聯(lián)苯]-4-基)-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氫喹啉-3-羧酸乙酯;ITD-1,TGF-Β信號傳導(dǎo)的抑制劑 |
| 英文名稱 | ITD-1 |
| 英文同義詞 | ITD-1;4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester;AOB6123;SCHEMBL3239096;Ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate;3-Quinolinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-, ethyl ester;CS-1731;ITD1;ITD-1;ITD 1 |
| CAS號 | 1099644-42-4 |
| 分子式 | C27H29NO3 |
| 分子量 | 415.52 |
| EINECS號 | |
| 相關(guān)類別 | 小分子抑制劑;小分子抑制劑，天然產(chǎn)物;抑制劑;Inhibitors |
| Mol文件 | 1099644-42-4.mol |
| 結(jié)構(gòu)式 |  |
ITD 1 性質(zhì)
| 沸點(diǎn) | 569.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.18±0.1 g/cm3(Predicted) |
| 儲存條件 | 2-8°C |
| 溶解度 | DMSO 中≥28.05 mg/mL；不溶于水；不溶于乙醇 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 1.33±0.70(Predicted) |
| 顏色 | 淺黃至黃色 |
| Target | Value |
|
TGF-β
() |
ITD-1 potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A. HEK293T cells are transfected with a Smad4 response element driving luciferase (SBE4-Luc) to test whether ITD-1 blocks Activin A/Nodal and/or TGFβ signaling, which utilize the same intracellular signaling cascade through Smad4. ITD-1 strongly inhibits TGFβ2 signaling with similar efficacy (92% vs. 99% respectively), but with lower potency compared to SB-431542, an ACVR1B/TGFBR1 kinase inhibitor (IC 50 = 850nM vs. 70nM respectively), and is a weak and partial inhibitor of Activin A signals. ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. ITD-1 reveals an unexpected role for TGFβ signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors .
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-12704 | ITD-1 | 1 mg | 360元 | |
| 2024/11/08 | HY-12704 | ITD 1 ITD-1 | 1099644-42-4 | 5mg | 700元 |