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Picamilon

Picamilon Suppliers list
Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8617531153977
Email: allison@yan-xi.com
Products Intro: Product Name:Pikamilon
CAS:34562-97-5
Purity:0.99 Package:1kg Remarks:Factory direct sales
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:Pikamilone
CAS:34562-97-5
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:Pikamilone
CAS:34562-97-5
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:4-(nicotinamido)butanoic acid
CAS:34562-97-5
Purity:99% Package:100g,1kg
Company Name: Zhengzhou Alfa Chemical Co.,Ltd
Tel: +8618530059196
Email: sale04@alfachem.cn
Products Intro: CAS:34562-97-5
Purity:96% Package:5g; 25g; 100g; 500g; 1kg; 25kg

Picamilon manufacturers

  • Pikamilone
  • Pikamilone pictures
  • $0.00 / 25Kg/Bag
  • 2025-02-18
  • CAS:34562-97-5
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20ton
  • Pikamilone
  • Pikamilone pictures
  • $50.00 / 1KG
  • 2025-02-18
  • CAS:34562-97-5
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5000KG
  • Pikamilone
  • Pikamilone pictures
  • $50.00 / 1mL
  • 2024-11-19
  • CAS:34562-97-5
  • Min. Order:
  • Purity: 98.25%
  • Supply Ability: 10g
Picamilon Basic information
Description Clinical Use
Product Name:Picamilon
Synonyms:4-((Pyridine-3-carbonyl)-amino)-butyric acid;Pikamiline;PikamiloneHCl;3-[(3-Carboxypropyl)carbamoyl]pyridine;PIKAMILON;4-Nicotinoylamino-butylric acid;PIKAMILONE HYDROCHLORIDE;NICOTINOYL-GABA
CAS:34562-97-5
MF:C10H12N2O3
MW:208.21
EINECS:1308068-626-2
Product Categories:Other APIs;API;Chemistry;Heterocycles;34562-97-5
Mol File:34562-97-5.mol
Picamilon Structure
Picamilon Chemical Properties
Melting point 211.0 to 215.0 °C
Boiling point 522.4±30.0 °C(Predicted)
density 1.245
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Slightly)
form Solid
pka4.60±0.10(Predicted)
color White to Off-White
InChIInChI=1S/C10H12N2O3/c13-9(14)4-2-6-12-10(15)8-3-1-5-11-7-8/h1,3,5,7H,2,4,6H2,(H,12,15)(H,13,14)
InChIKeyNAJVRARAUNYNDX-UHFFFAOYSA-N
SMILESC(O)(=O)CCCNC(C1=CC=CN=C1)=O
CAS DataBase Reference34562-97-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
HazardClass IRRITANT
HS Code 2933599590
MSDS Information
Picamilon Usage And Synthesis
DescriptionPikamilone is a drug having a central (vegetotropic and vascular) and peripheral (vasodilating) mechanisms of action.
Clinical UsePikamilone treatment of benign prostatic hyperplasia
Pikamilone is an original drug of Russian produce having a central (vegetotropic and vascular) and peripheral (vasodilating) mechanisms of action. The drug was tried as monotherapy in elderly patients with benign prostatic hyperplasia who had symptoms of the lower urinary tracts to estimate its effect on local and general mechanisms of nervous and vascular regulation of detruzor function in infravesical obstruction.
https://pubmed.ncbi.nlm.nih.gov/11150159/
Description Picamilon: an analogue of the neurotransmitter γ-aminobutyric acid (GABA)
Picamilon is a derivative of γ-aminobutyric acid (GABA) and nicotinic acid developed in 1970 by the All-Union Vitamin Research Institute to increase central nervous system (CNS) levels of γ-aminobutyric acid (GABA). Drugs that can mimic or increase GABA activity in the brain have the potential to provide anti-anxiety and anti-convulsive effects. GABA itself, when consumed orally, does not cross the blood-brain barrier. Much research has, therefore, been devoted to developing orally active agents that have GABA-like effects. Both gabapentin (a GABA analogue) and picamilon were designed to be orally administered drugs that cross the blood-brain barrier and provide inhibitory CNS effects. Picamilon, prescribed in dosages from 50 mg to 200 mg, can cross the blood-brain barrier in animal models and, once in the CNS, is hydrolyzed into GABA and nicotinic acid. The released GABA could potentially have inhibitory properties, including anti-anxiety and anti-convulsant effects. Nicotinic acid would also be released, potentially leading to dilation of CNS blood vessels. The FDA has never approved picamilon for use in the USA, but picamilon is used in Russia to treat various neurological conditions[1].
UsesNicotinoyl-γ-aminobutyric Acid is a pro-drug of γ-Aminobutyric Acid (A602920). Studies show that Nicotinoyl-γ-aminobutyric Acid is involved in the regulation of the processes in the brain of streptozotocin-induced diabetic rats.
Usesanti-cancer agent
PharmacokineticsBecause Picamilon can dramatically increase blood flow and circulation within the brain, picamilon is used as a nootropic. Also used for the treatment of depression, anxiety, and migraine, picamilon works by crossing the blood-brain barrier, after which it is hydrolyzed into GABA and nicotinic acid. In addition, picamilon has extremely low toxicity and no allergenic or carcinogenic properties. An animal study has shown that picamilon is rapidly absorbed (Tmax = 0.23 h) and penetrates well through the blood-brain barrier in mice. At oral administration, the drug bioavailability in mice was 21.9% and in rats between 53% and 78.9%[2].
References [1] Bharathi Avula. “Identification and quantification of vinpocetine and picamilon in dietary supplements sold in the United States.” Drug Testing and Analysis 8 3–4 (2015): 334–343.
[2] Wenqi Cui . “Determination of picamilon concentration in human plasma by liquid chromatography–tandem mass spectrometry.” Journal of Chromatography B 878 15 (2010): Pages 1181-1184.
Tag:Picamilon(34562-97-5) Related Product Information
Pyridine Glycine CARBONYL SULFIDE PYRAZOPHOS L(+)-2-Aminobutyric acid 3-Aminopyridine 4-Aminobutyric acid DL-3-Aminobutyric acid 6-Aminocaproic acid DL-2-Aminobutyric acid D-2-Aminobutyric acid r-Amino Butryric Acid Pikamilone sodium N-(5-hydroxynicotinoyl)-L-glutamic acid Glutamic acid, N-(2-chloronicotinoyl)- Pikamilone DL-2,4-Diaminobutanoic acid 1-[(2-hydroxypyridin-3-yl)carbonyl]piperidine-4-carboxylic acid

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