| Identification | More | [Name]
Pikamilone | [CAS]
34562-97-5 | [Synonyms]
4-[(3-PYRIDINYLCARBONYL)AMINO]BUTANOIC ACID
4-(3-PYRIDYLCARBOXAMIDO)BUTYRIC ACID
4-(NICOTINAMIDO)BUTANOIC ACID
4-[(PYRIDIN-3-YLCARBONYL)AMINO]BUTANOIC ACID
N-(3-CARBOXYPROPYL) NICOTINAMIDE
NICOTINOYL-GABA
PIKAMILONE HYDROCHLORIDE
Pikamiline
PikamiloneHCl
3-[(3-Carboxypropyl)carbamoyl]pyridine
PIKAMILON
4-Nicotinoylamino-butylric acid
4-((Pyridine-3-carbonyl)-amino)-butyric acid
4-Nicotinoylamino-butyric acid
Pikamilone
Pikamilone sodium sale | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C10H12N2O3 | [MDL Number]
MFCD08272808 | [Molecular Weight]
208.21 | [MOL File]
34562-97-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
211.0 to 215.0 °C | [Boiling point ]
522.4±30.0 °C(Predicted) | [density ]
1.245 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
Solid | [pka]
4.60±0.10(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C10H12N2O3/c13-9(14)4-2-6-12-10(15)8-3-1-5-11-7-8/h1,3,5,7H,2,4,6H2,(H,12,15)(H,13,14) | [InChIKey]
NAJVRARAUNYNDX-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CCCNC(C1=CC=CN=C1)=O | [CAS DataBase Reference]
34562-97-5(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Description]
Pikamilone is a drug having a central (vegetotropic and vascular) and peripheral (vasodilating) mechanisms of action. | [Clinical Use]
Pikamilone treatment of benign prostatic hyperplasia
Pikamilone is an original drug of Russian produce having a central (vegetotropic and vascular) and peripheral (vasodilating) mechanisms of action. The drug was tried as monotherapy in elderly patients with benign prostatic hyperplasia who had symptoms of the lower urinary tracts to estimate its effect on local and general mechanisms of nervous and vascular regulation of detruzor function in infravesical obstruction.
https://pubmed.ncbi.nlm.nih.gov/11150159/ |
| Hazard Information | Back Directory | [Uses]
anti-cancer agent | [Pharmacokinetics]
Because Picamilon can dramatically increase blood flow and circulation within the brain, picamilon is used as a nootropic. Also used for the treatment of depression, anxiety, and migraine, picamilon works by crossing the blood-brain barrier, after which it is hydrolyzed into GABA and nicotinic acid. In addition, picamilon has extremely low toxicity and no allergenic or carcinogenic properties. An animal study has shown that picamilon is rapidly absorbed (Tmax = 0.23 h) and penetrates well through the blood-brain barrier in mice. At oral administration, the drug bioavailability in mice was 21.9% and in rats between 53% and 78.9%[2].
| [References]
[1] Bharathi Avula. “Identification and quantification of vinpocetine and picamilon in dietary supplements sold in the United States.” Drug Testing and Analysis 8 3–4 (2015): 334–343.
[2] Wenqi Cui . “Determination of picamilon concentration in human plasma by liquid chromatography–tandem mass spectrometry.” Journal of Chromatography B 878 15 (2010): Pages 1181-1184.
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