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Nucleoside drugs

Many of the purine pyrimidine nucleoside analogues, which are promising antiviral compounds, are antiviral in tissue culture and in vivo. The compounds with selective inhibition of the virus, low toxicity, and effective in animals develop into nuclei Glycosides antiviral drugs. Currently, nucleoside drugs that are effective in clinical applications, have commodities, and have been recognized include iodine glycosides, trifluorothymidine, cyclosine, a sugar adenosine, acyclovir and so on. Nucleoside drugs that have a certain effect in clinical trials, have goods in some countries, yet to be recognized include ribavirin, arabinosyl adenosine monophosphate, bromide uridine and so on. Clinical trials are under way to observe the effect include fluoro-iodine cytosine. The new anti-viral nucleoside compounds have been reported is still in research and development. Nucleoside analogs are nucleic acid antimetabolites that are structurally analogous to nucleic acid precursors, competing for nucleic acid synthase enzyme systems, replacing normal nucleic acid precursors, or inhibiting nucleic acid synthetases, blocking viral or cellular nucleic acid synthesis, selectively inhibiting viral nucleic acids , while have little effect on the synthesis of nucleic acid.
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Structure Chemical Name CAS MF
6-Methoxy-9-(2-C-Methyl-beta-D-ribofuranosyl)purine 6-Methoxy-9-(2-C-Methyl-beta-D-ribofuranosyl)purine 565450-78-4 C12H16N4O5
2'-Deoxyguanosine monohydrate 2'-Deoxyguanosine monohydrate 312693-72-4 C10H15N5O5
5-(Hydroxymethyl)-2'-deoxycytidine 5-(Hydroxymethyl)-2'-deoxycytidine 7226-77-9 C10H15N3O5
2'-Fluoro-2'-deoxy-ara-A-3'-phosphoramidite 2'-Fluoro-2'-deoxy-ara-A-3'-phosphoramidite 329187-86-2 C47H51FN7O7P
3'-O-(2-Methoxyethyl)guanosine 3'-O-(2-Methoxyethyl)guanosine 256224-03-0 C13H19N5O6
5'-O-Acetyl-5-acetyloxymethyluridine 5'-O-Acetyl-5-acetyloxymethyluridine 2305416-11-7 C14H18N2O9
1-MethylInosine 1-MethylInosine 2140-73-0 C11H14N4O5
β-nicotinamide mononucleotide, reduced form, disodium salt(NMNH) β-nicotinamide mononucleotide, reduced form, disodium salt(NMNH) 108347-85-9 C11H18N2NaO8P
dGTP 100mM dGTP 100mM
β-Nicotinamide adenine dinucleotide reduced dipotassium β-Nicotinamide adenine dinucleotide reduced dipotassium 104809-32-7 C21H27K2N7O14P2
DMT-dU-CE Phosphoramidite DMT-dU-CE Phosphoramidite 109389-30-2 C39H47N4O8P
xanthane hydride xanthane hydride 6846-35-1 C2H2N2S3
Nicotinamide riboside chloride Nicotinamide riboside chloride 23111-00-4 C11H15ClN2O5
5-Propargylamino-dCTP 5-Propargylamino-dCTP 115899-39-3 C12H19N4O13P3
2'-OMe-ibu-G Phosphoramidite 2'-OMe-ibu-G Phosphoramidite 150780-67-9 C45H56N7O9P
8-Azaguanosine 8-Azaguanosine 2133-80-4 C9H12N6O5
3′-Deoxy-3′-fluorouridine 3′-Deoxy-3′-fluorouridine 57944-13-5 C9H11FN2O5
3'-O-MOE-A(Bz)-2'-CED-phosphoramidite 3'-O-MOE-A(Bz)-2'-CED-phosphoramidite 256224-01-8 C50H58N7O9P
6-methylpurine riboside 6-methylpurine riboside 14675-48-0 C11H14N4O4
Ac-rC Phosphoramidite Ac-rC Phosphoramidite 121058-88-6 C47H64N5O9PSi
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione 666816-98-4 C10H9BrN4O2
1,4-Dideoxy-1,4-epithio-D-ribitol 1,4-Dideoxy-1,4-epithio-D-ribitol 190315-43-6 C5H10O3S
Nucleoside Nucleoside
5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine 114745-26-5 C36H39N5O8
2-methylthioadenosine 2-methylthioadenosine 4105-39-9 C11H15N5O4S
Guanosine-5'-triphosphate disodium salt Guanosine-5'-triphosphate disodium salt 56001-37-7 C10H17N5NaO14P3
2'-O-Propygylguanosine 2'-O-Propygylguanosine 206552-86-5 C13H15N5O5
6-Bromopurine 6-Bromopurine 767-69-1 C5H3BrN4
2',3'-O-Isopropylideneguanosine 2',3'-O-Isopropylideneguanosine 362-76-5 C13H17N5O5
Adenosine 5′-diphosphate sodium salt Adenosine 5′-diphosphate sodium salt 20398-34-9 C10H16N5NaO10P2
9-(4-Acetoxy-2-acetoxymethyl-but-1-yl)-2-aminopurine 9-(4-Acetoxy-2-acetoxymethyl-but-1-yl)-2-aminopurine 126589-69-3 C14H19N5O4
3'-O-(4,4'-dimethoxytrityl)-thymidine 3'-O-(4,4'-dimethoxytrityl)-thymidine 76054-81-4 C31H32N2O7
β-Nicotinamide adenine dinucleotide sodium salt β-Nicotinamide adenine dinucleotide sodium salt 20111-18-6 C21H28N7NaO14P2
GUANINE SULFATE GUANINE SULFATE 10333-92-3 C5H7N5O5S
2'-Deoxyadenosine-5'-triphosphate, trisodiuM salt 2'-Deoxyadenosine-5'-triphosphate, trisodiuM salt 54680-12-5 C10H17N5NaO12P3
DMT-2'-F-Bz-dA DMT-2'-F-Bz-dA 136834-21-4 C38H34FN5O6
2'-O-MOE-A(Bz)-3'-phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite 251647-53-7 C50H58N7O9P
3'-O-MOE-G(iBu)-2'-phosphoramidite 3'-O-MOE-G(iBu)-2'-phosphoramidite 256224-06-3 C47H60N7O10P
DMT-2′Fluoro-dU Phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 146954-75-8 C39H46FN4O8P
Tributylammonium pyrophosphate Tributylammonium pyrophosphate 5975-18-8 C12H31NO7P2
2’-O-Methyl-rA(N-Bz)phosphoramidite 2’-O-Methyl-rA(N-Bz)phosphoramidite 110782-31-5 C48H54N7O8P
6-Hydrazinopurine 6-Hydrazinopurine 5404-86-4 C5H6N6
DMT-2μ-O-Me-rG(ib) amidite DMT-2μ-O-Me-rG(ib) amidite 251647-55-9 C47H60N7O10P
Doravirine Doravirine 1338225-97-0 C17H11ClF3N5O3
SQ 109 SQ 109 502487-67-4 C22H38N2
Thymidine-5'-monophosphate disodium salt Thymidine-5'-monophosphate disodium salt 33430-62-5 C10H16N2NaO8P
DMT-2'-F-dGiBu DMT-2'-F-dGiBu 144089-96-3 C35H36FN5O7
Deoxyribonucleoside Deoxyribonucleoside
2'-O-Methylcytidine 2'-O-Methylcytidine 2140-72-9 C10H15N3O5
2-Amino-6-iodopurine 2-Amino-6-iodopurine 19690-23-4 C5H4IN5
DMT-dT Phosphoramidite DMT-dT Phosphoramidite 98796-51-1 C40H49N4O8P
1-(2,4,6-Triisopropylphenylsulfonyl)imidazole 1-(2,4,6-Triisopropylphenylsulfonyl)imidazole 50257-40-4 C18H26N2O2S
Adenine hydrochloride hemihydrate Adenine hydrochloride hemihydrate 6055-72-7 C5H8ClN5O
2'-Deoxyadenosine 5'-phosphate 2'-Deoxyadenosine 5'-phosphate 653-63-4 C10H14N5O6P
Cytidine 5'-triphosphate disodium salt Cytidine 5'-triphosphate disodium salt 36051-68-0 C9H17N3NaO14P3
6-Methoxyguanine 6-Methoxyguanine 20535-83-5 C6H7N5O
5-FORMYLURACIL 5-FORMYLURACIL 1195-08-0 C5H4N2O3
N-Benzoyladenosine N-Benzoyladenosine 4546-55-8 C17H17N5O5
6-Chloropurine riboside 6-Chloropurine riboside 5399-87-1 C10H11ClN4O4
6-Dimethylaminopurine 6-Dimethylaminopurine 938-55-6 C7H9N5
ADENOSINE 5'-TRIPHOSPHATE DISODIUM SAL& ADENOSINE 5'-TRIPHOSPHATE DISODIUM SAL& 34369-07-8 C10H19N5NaO14P3
2'-Deoxyguanosine-5'-triphosphate trisodium salt 2'-Deoxyguanosine-5'-triphosphate trisodium salt 93919-41-6 C10H17N5NaO13P3
2-IODOADENOSINE 2-IODOADENOSINE 35109-88-7 C10H12IN5O4
Adenosine 3',5'-cyclic monophosphate sodium salt Adenosine 3',5'-cyclic monophosphate sodium salt 37839-81-9 C10H13N5NaO6P
N2-(2-METHYLPROPANOYL)-GUANOSINE N2-(2-METHYLPROPANOYL)-GUANOSINE 64350-24-9 C14H19N5O6
Adenine hydrochloride Adenine hydrochloride 2922-28-3 C5H6ClN5
5-Methylcytidine 5-Methylcytidine 2140-61-6 C10H15N3O5
2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine 7355-55-7 C6H6N4O
6-Amino-3,7-dihydro-2H-purin-2-one 6-Amino-3,7-dihydro-2H-purin-2-one 3373-53-3 C5H5N5O
N-Benzoyl-2'-deoxy-cytidine N-Benzoyl-2'-deoxy-cytidine 4836-13-9 C16H17N3O5
2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate 134790-39-9 C23H19F2N3O6
5,6-DIHYDROURACIL 5,6-DIHYDROURACIL 504-07-4 C4H6N2O2
N2-Isobutyryl-2'-deoxyguanosine N2-Isobutyryl-2'-deoxyguanosine 68892-42-2 C14H19N5O5
2'-Deoxycytidine-5'-monophosphoric acid 2'-Deoxycytidine-5'-monophosphoric acid 1032-65-1 C9H14N3O7P
2-Aminopurine 2-Aminopurine 452-06-2 C5H5N5
DITHIOURACIL DITHIOURACIL 2001-93-6 C4H4N2S2
1H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine 1H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine 1123-54-2 C4H4N6
6-AZATHYMINE 6-AZATHYMINE 932-53-6 C4H5N3O2
5-METHYLCYTOSINE HYDROCHLORIDE 5-METHYLCYTOSINE HYDROCHLORIDE 58366-64-6 C5H8ClN3O
N-2-Acetylguanine N-2-Acetylguanine 19962-37-9 C7H7N5O2
Flavin adenine dinucleotide disodium salt Flavin adenine dinucleotide disodium salt 84366-81-4 C27H34N9NaO15P2
5-METHYLCYTOSINE 5-METHYLCYTOSINE 554-01-8 C5H7N3O
2'-O-Methyladenosine 2'-O-Methyladenosine 2140-79-6 C11H15N5O4
5-Iodo-2'-deoxycytidine 5-Iodo-2'-deoxycytidine 611-53-0 C9H12IN3O4
DI-TERT-BUTYLDICHLOROSILANE DI-TERT-BUTYLDICHLOROSILANE 18395-90-9 C8H18Cl2Si
8-AZAGUANINE 8-AZAGUANINE 134-58-7 C4H4N6O
6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine 6-Chloro-9-beta-D-(2,3-isopropylidene)ribofuranosylpurine 39824-26-5 C13H15ClN4O4
5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine 5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine 68892-41-1 C35H37N5O7
3-ISOBUTYL-1-METHYLXANTHINE 3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2
5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine 67219-55-0 C37H35N3O7
2-Fluoroadenosine 2-Fluoroadenosine 146-78-1 C10H12FN5O4
5-Fluorouridine 5-Fluorouridine 316-46-1 C9H11FN2O6
Nicotinamide-N-oxide Nicotinamide-N-oxide 1986-81-8 C6H6N2O2
8-Bromoguanosine 8-Bromoguanosine 4016-63-1 C10H12BrN5O5
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6 C6H7ClN2O2
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 64325-78-6 C38H35N5O6
METHYL PHOSPHORODICHLORIDITE METHYL PHOSPHORODICHLORIDITE 3279-26-3 CH3Cl2OP
N-MESITYLENESULFONYLIMIDAZOLE N-MESITYLENESULFONYLIMIDAZOLE 50257-39-1 C12H14N2O2S
5-IODOURIDINE 5-IODOURIDINE 1024-99-3 C9H11IN2O6
2'-Deoxycytidine hydrochloride 2'-Deoxycytidine hydrochloride 3992-42-5 C9H14ClN3O4
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