NU 6027
|
1物価
選択條件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 生産者Sigma-Aldrich Japan
- 製品番號N4411
- 製品説明 ≥98% (HPLC)
- 英語製品説明NU6027 ≥98% (HPLC)
- 包裝単位5mg
- 価格￥31300
- 更新しました2018-12-25
- 購入
| 生産者 | 製品番號 | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | N4411 | ≥98% (HPLC) NU6027 ≥98% (HPLC) |
5mg | ￥31300 | 2018-12-25 | 購入 |
プロパティ
融點(diǎn) :252.5-253.7 °C(lit.)
沸點(diǎn) :549.2±60.0 °C(Predicted)
比重(密度) :1.53±0.1 g/cm3(Predicted)
貯蔵溫度 :2-8°C
溶解性 :DMSO: 15 mg/mL
酸解離定數(shù)(Pka) :2.52±0.10(Predicted)
外見 :Reddish-purple powder
色 :lavender
沸點(diǎn) :549.2±60.0 °C(Predicted)
比重(密度) :1.53±0.1 g/cm3(Predicted)
貯蔵溫度 :2-8°C
溶解性 :DMSO: 15 mg/mL
酸解離定數(shù)(Pka) :2.52±0.10(Predicted)
外見 :Reddish-purple powder
色 :lavender
安全情報(bào)
| 絵表示(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| 注意喚起語: | ||||||||
| 危険有害性情報(bào): |
|
|||||||
| 注意書き: |
|
説明
Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. NU 6027 inhibits both CDK1 and CDK2 with IC50 values of 2.9 and 2.2 μM, respectively. It has been shown to inhibit cellular ataxia telangiectasia mutated and Rad3-realted kinase activity (IC50 = 6.7 μM) and impair G2/M arrest in various human cancer cells, potentiating the cytotoxic effects of DNA-damaging, anticancer agents such as cisplatin.関連製品価格
SU 9516関連商品価格
- SU 9516
￥36000-153000