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3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

price.
  • ￥15700 - ￥63400
  • 化學(xué)名:
  • 英語(yǔ)名: 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
  • 別名:
  • CAS番號(hào): 1031206-36-6
  • 分子式: C18H16O4
  • 分子量: 296.32
  • EINECS:
  • MDL Number:MFCD12912419
2物価
選択條件：
ブランド
  • Sigma-Aldrich Japan
パッケージ
  • 5mg
  • 25mg
  • 生産者Sigma-Aldrich Japan
  • 製品番號(hào)I7160
  • 製品説明 ≥98% (HPLC), solid
  • 英語(yǔ)製品説明IMS2186 ≥98% (HPLC), solid
  • 包裝単位5mg
  • 価格￥15700
  • 更新しました2024-03-01
  • 購(gòu)入
  • 生産者Sigma-Aldrich Japan
  • 製品番號(hào)I7160
  • 製品説明 ≥98% (HPLC), solid
  • 英語(yǔ)製品説明IMS2186 ≥98% (HPLC), solid
  • 包裝単位25mg
  • 価格￥63400
  • 更新しました2021-03-23
  • 購(gòu)入
生産者 製品番號(hào) 製品説明 包裝単位 価格 更新時(shí)間 購(gòu)入
Sigma-Aldrich Japan I7160 ≥98% (HPLC), solid
IMS2186 ≥98% (HPLC), solid		 5mg ￥15700 2024-03-01 購(gòu)入
Sigma-Aldrich Japan I7160 ≥98% (HPLC), solid
IMS2186 ≥98% (HPLC), solid		 25mg ￥63400 2021-03-23 購(gòu)入

プロパティ

沸點(diǎn)  :535.7±50.0 °C(Predicted)
比重(密度)  :1.286±0.06 g/cm3(Predicted)
貯蔵溫度  :room temp
溶解性 :DMSO: >20mg/mL
外見(jiàn)  :solid
酸解離定數(shù)(Pka) :9.39±0.10(Predicted)
色 :white to off-white

安全情報(bào)

絵表示(GHS): GHS hazard pictograms
注意喚起語(yǔ): Warning
危険有害性情報(bào):
コード 危険有害性情報(bào) 危険有害性クラス 區(qū)分 注意喚起語(yǔ) シンボル P コード
H400 水生生物に強(qiáng)い毒性 水生環(huán)境有害性、急性毒性 1 警告 GHS hazard pictograms P273, P391, P501
注意書(shū)き:
P273 環(huán)境への放出を避けること。

説明

An anti-proliferative and anti-angiogenic compound. IMS2186 is a novel synthetic compound developed as an anti-CNV drug. The proposed mechanism of action under investigation, is blocking the cell cycle at G2 and inhibiting the production of PGE2/TNF-. The latter contributing to anti-angiogenic and antiinflammatory effects. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50= 0.1 M) and cell migration, which plays a role in many biological processes: inflammation, angiogenesis, and scar formation. The physicochemical structure of IMS2186 showed also that the free drug concentration in a physiological media (e.g., vitreous or saline) is 8-10 M above the IC50 for all these activities (0.1-3.0 M). Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.