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ChemicalBook >> CAS DataBase List >> 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one price.
  • $110 - $744
  • Product name: 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
  • CAS: 1031206-36-6
  • MF: C18H16O4
  • MW: 296.32
  • EINECS:
  • MDL Number:MFCD12912419
  • Synonyms:3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one;IMS2186;4H-1-Benzopyran-4-one, 2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-, (3E)-;(E)-3-(3-Hydroxy-4-methoxybenzylidene)-6-methylchroman-4-one;(3E)-2,3-Dihydro-3-[(3-Hydroxy-4-Methoxyphenyl)Methylene]-6-Methyl-4H-1-Benzopyran-4-One;IMS2186, 10 mM in DMSO
6 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 5MG
  • 10MG
  • 25MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000992
  • Product descriptionIMS2186 95.00%
  • Packaging5MG
  • Price$481
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000992
  • Product descriptionIMS2186 95.00%
  • Packaging10MG
  • Price$537.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000992
  • Product descriptionIMS2186 95.00%
  • Packaging25MG
  • Price$744
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberI7160
  • Product descriptionIMS2186 ≥98% (HPLC), solid
  • Packaging5mg
  • Price$127
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberI268653
  • Product descriptionIMS2186
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number452283
  • Product descriptionIMS2186
  • Packaging5mg
  • Price$340
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation INB0000992 IMS2186 95.00% 5MG $481 2021-12-16 Buy
American Custom Chemicals Corporation INB0000992 IMS2186 95.00% 10MG $537.6 2021-12-16 Buy
American Custom Chemicals Corporation INB0000992 IMS2186 95.00% 25MG $744 2021-12-16 Buy
Sigma-Aldrich I7160 IMS2186 ≥98% (HPLC), solid 5mg $127 2024-03-01 Buy
TRC I268653 IMS2186 10mg $110 2021-12-16 Buy
Usbiological 452283 IMS2186 5mg $340 2021-12-16 Buy

Properties

Boiling point :535.7±50.0 °C(Predicted)
Density :1.286±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: >20mg/mL
form :solid
pka :9.39±0.10(Predicted)
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Description

An anti-proliferative and anti-angiogenic compound. IMS2186 is a novel synthetic compound developed as an anti-CNV drug. The proposed mechanism of action under investigation, is blocking the cell cycle at G2 and inhibiting the production of PGE2/TNF-. The latter contributing to anti-angiogenic and antiinflammatory effects. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50= 0.1 M) and cell migration, which plays a role in many biological processes: inflammation, angiogenesis, and scar formation. The physicochemical structure of IMS2186 showed also that the free drug concentration in a physiological media (e.g., vitreous or saline) is 8-10 M above the IC50 for all these activities (0.1-3.0 M). Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.