| Identification | Back Directory | [Name]
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one | [CAS]
1031206-36-6 | [Synonyms]
IMS2186
IMS2186, 10 mM in DMSO
(E)-3-(3-Hydroxy-4-methoxybenzylidene)-6-methylchroman-4-one
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
(3E)-2,3-Dihydro-3-[(3-Hydroxy-4-Methoxyphenyl)Methylene]-6-Methyl-4H-1-Benzopyran-4-One
4H-1-Benzopyran-4-one, 2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-, (3E)- | [Molecular Formula]
C18H16O4 | [MDL Number]
MFCD12912419 | [MOL File]
1031206-36-6.mol | [Molecular Weight]
296.32 |
| Chemical Properties | Back Directory | [Boiling point ]
535.7±50.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: >20mg/mL | [form ]
solid | [pka]
9.39±0.10(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
IMS2186 is an anti-prileferative and anti-angiogenic compound. | [Biological Activity]
IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss. |
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Energy Chemical
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http://www.energy-chemical.com |
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