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ChemicalBook >> CAS DataBase List >> Tamoxifen

Tamoxifen

Tamoxifen price.
  • $32 - $2148.3
  • Product name: Tamoxifen
  • CAS: 10540-29-1
  • MF: C26H29NO
  • MW: 371.51
  • EINECS:234-118-0
  • MDL Number:MFCD00010454
  • Synonyms:(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine;2-[4-[(Z)-1,2-Di(phenyl)but-1-enyl]phenoxy]-N,N-dimethylethanamine;2-[4-[(Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine;2-[p-[(Z)-1,2-Diphenyl-1-butenyl]phenyloxy]-N,N-dimethylethanamine;N,N-Dimethyl-2-[p-[(Z)-1,2-diphenyl-1-butenyl]phenoxy]ethanamine;C07108;Tamoxifen,(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine;1-p-β-DiMethylaMinoethoxyphenyl-trans-1,2-diphenylbut-1-ene
37 prices
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Brand
  • Acrotein
  • Adipogen Life Sciences
  • AHH
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 25mg
  • 100
  • 1mg
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  • 100mg
  • 0.5G
  • 500mg
  • 1ML
  • 1g
  • 2.5G
  • 5g
  • 10g
  • 25G
  • 100g
  • ManufacturerAcrotein
  • Product numberDM-3401
  • Product descriptionTamoxifen 97%
  • Packaging100g
  • Price$825
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-T0200-G001
  • Product descriptionTamoxifen ≥98%(NMR)
  • Packaging1g
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberAPI-1289
  • Product descriptionTamoxifen 98%
  • Packaging100g
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ92974
  • Product descriptionTamoxifen
  • Packaging100g
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63509
  • Product descriptionTamoxifen, 98%
  • Packaging500mg
  • Price$125
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63509
  • Product descriptionTamoxifen, 98%
  • Packaging1g
  • Price$206
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63509
  • Product descriptionTamoxifen, 98%
  • Packaging5g
  • Price$847
  • Updated2024-03-01
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004316
  • Product descriptionTAMOXIFEN 95.00%
  • Packaging2.5G
  • Price$847
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004316
  • Product descriptionTAMOXIFEN 95.00%
  • Packaging25G
  • Price$2148.3
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5965
  • Product descriptionTamoxifen
  • Packaging1g
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5965
  • Product descriptionTamoxifen
  • Packaging5g
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5965
  • Product descriptionTamoxifen
  • Packaging10g
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBT164438
  • Product descriptionTamoxifen
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27190
  • Product descriptionTamoxifen
  • Packaging5mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13258
  • Product descriptionTamoxifen ≥95%
  • Packaging500mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27190
  • Product descriptionTamoxifen
  • Packaging25mg
  • Price$61
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Acrotein DM-3401 Tamoxifen 97% 100g $825 2021-12-16 Buy
Adipogen Life Sciences CDX-T0200-G001 Tamoxifen ≥98%(NMR) 1g $59 2021-12-16 Buy
AHH API-1289 Tamoxifen 98% 100g $500 2021-12-16 Buy
AK Scientific J92974 Tamoxifen 100g $220 2021-12-16 Buy
Alfa Aesar J63509 Tamoxifen, 98% 500mg $125 2024-03-01 Buy
Alfa Aesar J63509 Tamoxifen, 98% 1g $206 2024-03-01 Buy
Alfa Aesar J63509 Tamoxifen, 98% 5g $847 2024-03-01 Buy
American Custom Chemicals Corporation API0004316 TAMOXIFEN 95.00% 2.5G $847 2021-12-16 Buy
American Custom Chemicals Corporation API0004316 TAMOXIFEN 95.00% 25G $2148.3 2021-12-16 Buy
ApexBio Technology B5965 Tamoxifen 1g $65 2021-12-16 Buy
ApexBio Technology B5965 Tamoxifen 5g $210 2021-12-16 Buy
ApexBio Technology B5965 Tamoxifen 10g $360 2021-12-16 Buy
Biosynth Carbosynth BT164438 Tamoxifen 100mg $50 2021-12-16 Buy
Cayman Chemical 27190 Tamoxifen 5mg $32 2024-03-01 Buy
Cayman Chemical 13258 Tamoxifen ≥95% 500mg $57 2024-03-01 Buy
Cayman Chemical 27190 Tamoxifen 25mg $61 2024-03-01 Buy

Properties

Melting point :97-98 °C(lit.)
Boiling point :501.18°C (rough estimate)
Density :1.0630 (rough estimate)
vapor pressure :0Pa at 25℃
refractive index :1.6000 (estimate)
storage temp. :2-8°C
solubility :H2O: insoluble <0.1% at 20°C
form :Solid
pka :pKa 8.71(H2O t = 25 I = 0.025) (Uncertain)
color :Crystals from pet ether
Water Solubility :Insoluble in water. Soluble in methanol, ethanol, propanol or propylene glycol.Soluble in dimethyl sulfoxide, dichloromethane and ethanol. Insoluble in water.
Merck :13,9137
Stability :Light Sensitive
InChIKey :NKANXQFJJICGDU-QPLCGJKRSA-N
LogP :6.3 at 20℃
CAS DataBase Reference :10540-29-1(CAS DataBase Reference)
IARC :1 (Vol. 66, 100A) 2012
EPA Substance Registry System :Tamoxifen (10540-29-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

There are two homologous nuclear receptors for the hormone 17β-estradiol (estrogen), commonly called ERα and ERβ. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is a selective estrogen receptor modulator, evoking tissue-dependent effects. It is an antagonist of ER action in breast tissue and breast cancer cells and is reported to be effective in the treatment of early breast cancer to prevent tumor growth. Importantly, tamoxifen has been reported to act as an ER agonist in bone and blood vessels, helping to minimize osteoporosis and reduce the risk of cardiovascular disease in post-menopausal women. Also, tamoxifen is a partial ER agonist in uterine tissues and is reported to increase the risk of endometrial carcinoma.

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