TH287
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- $44 - $2931
- Product name: TH287
- CAS: 1609960-30-6
- MF: C11H10Cl2N4
- MW: 269.13
- EINECS:-0
- MDL Number:MFCD29035111
- Synonyms:TH287 hydrochloride;TH287;6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine;6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride;6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine;TH287;TH-287;CS-1671;TH287, >98%
25 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 2x25mg
- 50mg
- 100mg
- 500mg
- 1g
- 250mg
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberSYN5236
- Product descriptionTH287
- Packaging50mg
- Price$745
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number6711DW
- Product description6-(2,3-Dichlorophenyl)-N~4~-Methylpyrimidine-2,4-Diamine
- Packaging500mg
- Price$2931
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5849
- Product descriptionTH287
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5849
- Product descriptionTH287
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5849
- Product descriptionTH287
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5849
- Product descriptionTH287
- Packaging100mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2271
- Product descriptionTH287 hydrochloride 98%
- Packaging2x25mg
- Price$528
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611851
- Product descriptionTH-287 hydrochloride
- Packaging10mg
- Price$268.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611851
- Product descriptionTH-287 hydrochloride
- Packaging50mg
- Price$593.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611851
- Product descriptionTH-287 hydrochloride
- Packaging100mg
- Price$970.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18132
- Product descriptionTH287 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18132
- Product descriptionTH287 ≥98%
- Packaging5mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18132
- Product descriptionTH287 ≥98%
- Packaging10mg
- Price$151
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM167747
- Product description6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine 98%
- Packaging100mg
- Price$355
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4511
- Product descriptionTH287 98.14%
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4511
- Product descriptionTH287 98.14%
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5236 | TH287 | 50mg | $745 | 2021-12-16 | Buy |
| AK Scientific | 6711DW | 6-(2,3-Dichlorophenyl)-N~4~-Methylpyrimidine-2,4-Diamine | 500mg | $2931 | 2021-12-16 | Buy |
| ApexBio Technology | B5849 | TH287 | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| ApexBio Technology | B5849 | TH287 | 5mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | B5849 | TH287 | 10mg | $90 | 2021-12-16 | Buy |
| ApexBio Technology | B5849 | TH287 | 100mg | $470 | 2021-12-16 | Buy |
| Axon Medchem | Axon2271 | TH287 hydrochloride 98% | 2x25mg | $528 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611851 | TH-287 hydrochloride | 10mg | $268.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611851 | TH-287 hydrochloride | 50mg | $593.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611851 | TH-287 hydrochloride | 100mg | $970.7 | 2021-12-16 | Buy |
| Cayman Chemical | 18132 | TH287 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18132 | TH287 ≥98% | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 18132 | TH287 ≥98% | 10mg | $151 | 2024-03-01 | Buy |
| Chemenu | CM167747 | 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine 98% | 100mg | $355 | 2021-12-16 | Buy |
| ChemScene | CS-4511 | TH287 98.14% | 5mg | $75 | 2021-12-16 | Buy |
| ChemScene | CS-4511 | TH287 98.14% | 10mg | $120 | 2021-12-16 | Buy |
Properties
Boiling point :512.2±60.0 °C(Predicted)
Density :1.440±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :5.91±0.10(Predicted)
form :powder
color :white to beige
Density :1.440±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :5.91±0.10(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell lines (IC50s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC50s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).More related product prices
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