N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
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- $40 - $4473
- Product name: N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
- CAS: 918633-87-1
- MF: C9H16Br2N5O4P
- MW: 449.04
- EINECS:
- MDL Number:MFCD22420822
- Synonyms:N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester;TH 302;EvofosfaMide;TH-302, >=98%;TH-302 (Evofosfamide);(1-methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)diamidophosphate;EOS-61724;Evofosfamide(TH 302)
17 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 30MG
- 50MG
- 100MG
- 200mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberX5809
- Product description(1-Methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)phosphorodiamidate
- Packaging250mg
- Price$667
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX5809
- Product description(1-Methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)phosphorodiamidate
- Packaging1g
- Price$1580
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005715
- Product descriptionTH-302 95.00%
- Packaging30MG
- Price$1558
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005715
- Product descriptionTH-302 95.00%
- Packaging50MG
- Price$2446.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005715
- Product descriptionTH-302 95.00%
- Packaging100MG
- Price$4473
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3872
- Product descriptionTH-302
- Packaging5mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3872
- Product descriptionTH-302
- Packaging10mM(in 1mL DMSO)
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22195
- Product descriptionTH-302 ≥95%
- Packaging25mg
- Price$590
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22195
- Product descriptionTH-302 ≥95%
- Packaging10mg
- Price$276
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22195
- Product descriptionTH-302 ≥95%
- Packaging5mg
- Price$168
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22195
- Product descriptionTH-302 ≥95%
- Packaging1mg
- Price$40
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM191919
- Product descriptionEvofosfamide 98%
- Packaging100mg
- Price$1095
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000257
- Product descriptionEvofosfamide(TH302) 98+%
- Packaging5mg
- Price$182
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000257
- Product descriptionEvofosfamide(TH302) 98+%
- Packaging100mg
- Price$939
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7689
- Product descriptionEvofosfamide(TH-302) >98%
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number67266
- Product descriptionTH-302
- Packaging200mg
- Price$3400
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5809 | (1-Methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)phosphorodiamidate | 250mg | $667 | 2021-12-16 | Buy |
| AK Scientific | X5809 | (1-Methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)phosphorodiamidate | 1g | $1580 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005715 | TH-302 95.00% | 30MG | $1558 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005715 | TH-302 95.00% | 50MG | $2446.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005715 | TH-302 95.00% | 100MG | $4473 | 2021-12-16 | Buy |
| ApexBio Technology | A3872 | TH-302 | 5mg | $190 | 2021-12-16 | Buy |
| ApexBio Technology | A3872 | TH-302 | 10mM(in 1mL DMSO) | $270 | 2021-12-16 | Buy |
| Cayman Chemical | 22195 | TH-302 ≥95% | 25mg | $590 | 2024-03-01 | Buy |
| Cayman Chemical | 22195 | TH-302 ≥95% | 10mg | $276 | 2024-03-01 | Buy |
| Cayman Chemical | 22195 | TH-302 ≥95% | 5mg | $168 | 2024-03-01 | Buy |
| Cayman Chemical | 22195 | TH-302 ≥95% | 1mg | $40 | 2024-03-01 | Buy |
| Chemenu | CM191919 | Evofosfamide 98% | 100mg | $1095 | 2021-12-16 | Buy |
| Crysdot | CD31000257 | Evofosfamide(TH302) 98+% | 5mg | $182 | 2021-12-16 | Buy |
| Crysdot | CD31000257 | Evofosfamide(TH302) 98+% | 100mg | $939 | 2021-12-16 | Buy |
| DC Chemicals | DC7689 | Evofosfamide(TH-302) >98% | 100mg | $550 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 67266 | TH-302 | 200mg | $3400 | 2021-12-16 | Buy |
Properties
Melting point :97-98°C
Boiling point :565.4±60.0 °C(Predicted)
Density :1.97
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :0.34±0.70(Predicted)
form :Solid
color :Off-White to Pale Yellow
Boiling point :565.4±60.0 °C(Predicted)
Density :1.97
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :0.34±0.70(Predicted)
form :Solid
color :Off-White to Pale Yellow
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
TH-302 is a hypoxia-activated prodrug and DNA alkylating agent with anticancer activity. It is selectively cytotoxic to H460 human non-small cell lung cancer (NSCLC) cells grown under hypoxic over normoxic conditions (IC50s = 0.019 and 5.1 μM, respectively). Under hypoxic conditions, TH-302 undergoes a one-electron reduction to form an active radical intermediate that is then further reduced to form a DNA-intercalating hydroxylamine. Under normoxic conditions, the radical intermediate is quenched and induces reformation of the inactive nitroazole prodrug. TH-302 reduces survival of H460 and HT-29 cells in a clonogenic assay (IC50s = 0.2 and 0.2 μM, respectively). In vivo, TH-302 (33 mg/kg per day) inhibits primary tumor growth by 41% in an MIA PaCa-2-RFP mouse orthotopic xenograft model. It inhibits tumor growth by greater than 40% in Calu-6 NSCLC, H82 small cell lung, A375 melanoma, PC-3 prostate, and BxPC-3 pancreatic cancer mouse xenograft models when administered at 50 mg/kg.Related product price
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Suppliers and manufacturers
career henan chemical co
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
ANHUI WITOP BIOTECH CO., LTD
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Shanghai Acmec Biochemical Technology Co., Ltd.
$7.00 /1KG
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester CAS:918633-87-1
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester CAS:918633-87-1
