98% purity available from supplier Axon Medchem, prime source of life science reagents for your research" />

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TH 287 hydrochloride

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2271

CAS [1638211-05-8]

MF C11H10Cl2N4.HCl
MW 305.59

  • Purity: 98%
  • Soluble in DMSO

TH 287 hydrochloride

Description

First-in-class MTH1 inhibitor (IC50 value 0.8 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells. TH 287 shows no relevant inhibitory effect for any of the other tested nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, nor for other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase and ITPA).
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5 mg $104.50 In Stock
25 mg $357.50 In Stock
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2 x 5 mg $154.00 In Stock
2 x 25 mg $528.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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