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ChemicalBook >> CAS DataBase List >> SB 203580

SB 203580

SB 203580 price.
  • $26 - $2151
  • Product name: SB 203580
  • CAS: 152121-47-6
  • MF: C21H16FN3OS
  • MW: 377.43
  • EINECS:
  • MDL Number:MFCD00922198
  • Synonyms:SB 203580 HYDROCHLORIDE;SB 2035850;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL;4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULPHONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE HYDROCHLORIDE; 4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine
76 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
Package
  • 1
  • 1mg
  • 10mg
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  • 1unit
  • 5mg
  • 10
  • 50
  • 10mM(in 1mL DMSO)
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0030-M025
  • Product descriptionSB 203580 ≥98%
  • Packaging25mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1074
  • Product descriptionSB 203580
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ61482
  • Product descriptionSB 203580, 98%
  • Packaging100mg
  • Price$356
  • Updated2023-06-20
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ61482
  • Product descriptionSB 203580, 98%
  • Packaging50mg
  • Price$224
  • Updated2023-06-20
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ61482
  • Product descriptionSB 203580, 98%
  • Packaging25mg
  • Price$156
  • Updated2023-06-20
  • Buy
  • ManufacturerAmbeed
  • Product numberA248150
  • Product descriptionSB 203580 98+%
  • Packaging5mg
  • Price$26
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA248150
  • Product descriptionSB 203580 98+%
  • Packaging10mg
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA248150
  • Product descriptionSB 203580 98+%
  • Packaging50mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA248150
  • Product descriptionSB 203580 98+%
  • Packaging100mg
  • Price$195
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA248150
  • Product descriptionSB 203580 98+%
  • Packaging250mg
  • Price$289
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA248150
  • Product descriptionSB 203580 98+%
  • Packaging1g
  • Price$706
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000222
  • Product descriptionSB 203580 95.00%
  • Packaging100MG
  • Price$854.01
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000222
  • Product descriptionSB 203580 95.00%
  • Packaging50MG
  • Price$766.69
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000222
  • Product descriptionSB 203580 95.00%
  • Packaging25MG
  • Price$720.12
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8254
  • Product descriptionSB 203580
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8254
  • Product descriptionSB 203580
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-0030-M025 SB 203580 ≥98% 25mg $300 2021-12-16 Buy
AK Scientific SYN1074 SB 203580 5mg $85 2021-12-16 Buy
Alfa Aesar J61482 SB 203580, 98% 100mg $356 2023-06-20 Buy
Alfa Aesar J61482 SB 203580, 98% 50mg $224 2023-06-20 Buy
Alfa Aesar J61482 SB 203580, 98% 25mg $156 2023-06-20 Buy
Ambeed A248150 SB 203580 98+% 5mg $26 2021-12-16 Buy
Ambeed A248150 SB 203580 98+% 10mg $41 2021-12-16 Buy
Ambeed A248150 SB 203580 98+% 50mg $108 2021-12-16 Buy
Ambeed A248150 SB 203580 98+% 100mg $195 2021-12-16 Buy
Ambeed A248150 SB 203580 98+% 250mg $289 2021-12-16 Buy
Ambeed A248150 SB 203580 98+% 1g $706 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000222 SB 203580 95.00% 100MG $854.01 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000222 SB 203580 95.00% 50MG $766.69 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000222 SB 203580 95.00% 25MG $720.12 2021-12-16 Buy
ApexBio Technology A8254 SB 203580 1unit $28 2021-12-16 Buy
ApexBio Technology A8254 SB 203580 10mM(in 1mL DMSO) $55 2021-12-16 Buy

Properties

Melting point :144-146
Boiling point :615.6±55.0 °C(Predicted)
Density :1.4
storage temp. :-20°C
solubility :DMSO: 50 mg/mL
form :solid
pka :9.60±0.10(Predicted)
color :white to off-white
Stability :-200C
InChIKey :CDMGBJANTYXAIV-UHFFFAOYSA-N
CAS DataBase Reference :152121-47-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

Description

Mitogen-activated protein kinases (MAPK) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. SB 203580 is a pyridinyl imidazole inhibitor of p38 MAPK that specifically blocks its kinase activity. SB 203580 does not however, disrupt JNK activity, which is activated by similar stressors to those which activate p38 MAPK. p38 MAPK activity in heat-shocked HeLa cells and osmotically stressed PC12 cells is inhibited by SB 203580 with an IC50 value of 0.6 μM. SB 203580 also prevents the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1) at IC50 values of 3-5 μM.

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