2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride
- $33 - $1348
- Product name: 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride
- CAS: 694433-59-5
- MF: C20H21N3O2
- MW: 335.4
- EINECS:
- MDL Number:MFCD20926329
- Synonyms:2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride;SB-505124 hydrate hydrochloride;2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-iMidazol-4-yl)-6-Methylpyridine;2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1- diMethylethyl)-1H-iMidazol-5-yl]-6-Methyl-pyridine;2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine;SB-505124 hydrochloride hydrate;2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine;2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine SB505124
39 prices
Selected condition:
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- Arctom
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2707AH
- Product descriptionSB-505124
- Packaging50mg
- Price$419
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114347
- Product descriptionSB-505124 98+%
- Packaging1mg
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114347
- Product descriptionSB-505124 98+%
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114347
- Product descriptionSB-505124 98+%
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114347
- Product descriptionSB-505124 98+%
- Packaging50mg
- Price$266
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114347
- Product descriptionSB-505124 98+%
- Packaging100mg
- Price$395
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114347
- Product descriptionSB-505124 98+%
- Packaging250mg
- Price$537
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114347
- Product descriptionSB-505124 98+%
- Packaging1g
- Price$1348
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007582
- Product descriptionSB-505124 HYDROCHLORIDE HYDRATE 95.00%
- Packaging5MG
- Price$756.58
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007582
- Product descriptionSB-505124 HYDROCHLORIDE HYDRATE 95.00%
- Packaging25MG
- Price$1226.1
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS436193
- Product descriptionSB-505124 ≥98%
- Packaging1mg
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS436193
- Product descriptionSB-505124 ≥98%
- Packaging5mg
- Price$64
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS436193
- Product descriptionSB-505124 ≥98%
- Packaging10mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60366
- Product descriptionSB505124 ≥98%
- Packaging5mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS436193
- Product descriptionSB-505124 ≥98%
- Packaging50mg
- Price$263
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS436193
- Product descriptionSB-505124 ≥98%
- Packaging100mg
- Price$391
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 2707AH | SB-505124 | 50mg | $419 | 2021-12-16 | Buy |
Ambeed | A114347 | SB-505124 98+% | 1mg | $33 | 2021-12-16 | Buy |
Ambeed | A114347 | SB-505124 98+% | 5mg | $65 | 2021-12-16 | Buy |
Ambeed | A114347 | SB-505124 98+% | 10mg | $110 | 2021-12-16 | Buy |
Ambeed | A114347 | SB-505124 98+% | 50mg | $266 | 2021-12-16 | Buy |
Ambeed | A114347 | SB-505124 98+% | 100mg | $395 | 2021-12-16 | Buy |
Ambeed | A114347 | SB-505124 98+% | 250mg | $537 | 2021-12-16 | Buy |
Ambeed | A114347 | SB-505124 98+% | 1g | $1348 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0007582 | SB-505124 HYDROCHLORIDE HYDRATE 95.00% | 5MG | $756.58 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0007582 | SB-505124 HYDROCHLORIDE HYDRATE 95.00% | 25MG | $1226.1 | 2021-12-16 | Buy |
Arctom | AS436193 | SB-505124 ≥98% | 1mg | $33 | 2021-12-16 | Buy |
Arctom | AS436193 | SB-505124 ≥98% | 5mg | $64 | 2021-12-16 | Buy |
Arctom | AS436193 | SB-505124 ≥98% | 10mg | $109 | 2021-12-16 | Buy |
Arctom | CFN60366 | SB505124 ≥98% | 5mg | $138 | 2021-12-16 | Buy |
Arctom | AS436193 | SB-505124 ≥98% | 50mg | $263 | 2021-12-16 | Buy |
Arctom | AS436193 | SB-505124 ≥98% | 100mg | $391 | 2021-12-16 | Buy |
Properties
Melting point :168 °C
Boiling point :509.7±50.0 °C(Predicted)
Density :1.202
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >10mg/mL
pka :11.26±0.10(Predicted)
form :powder
color :yellow
Boiling point :509.7±50.0 °C(Predicted)
Density :1.202
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >10mg/mL
pka :11.26±0.10(Predicted)
form :powder
color :yellow
Safety Information
Symbol(GHS): | |||||||||||||||||||||||||||||
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Signal word: | Warning | ||||||||||||||||||||||||||||
Hazard statements: |
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Precautionary statements: |
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Description
SB-505124 inhibits the TGF-β1 receptor serine/threonine kinase ALK5 with an IC50 value of 47 nM. Though it is a less potent antagonist of ALK4 (IC50 = 129 nM) and ALK7, SB-505124 selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK7-dependent activation of downstream SMAD2 and SMAD3 and TGF-β–induced MAP kinase pathway components without altering ALK1-3 or ALK6-induced SMAD signaling. In an assay determining in vitro phosphorylation of SMAD3, SB-505124 is more potent than SB-431452 with IC50 values of 47 versus 94 nM, respectively.More related product prices
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Suppliers and manufacturers
career henan chemical co
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$1.00 /1KG
2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride CAS:694433-59-5
2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride CAS:694433-59-5