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ChemicalBook >> CAS DataBase List >> Rhein

Rhein

Rhein price.
  • $5 - $2120
  • Product name: Rhein
  • CAS: 478-43-3
  • MF: C15H8O6
  • MW: 284.22
  • EINECS:207-521-4
  • MDL Number:MFCD00009618
  • Synonyms:chrysazin-3-carboxylicacid ;monorhein ;rheicacid ;RHUBARB YELLOW;RHEIN;TIMTEC-BB SBB001152;1,8-DIHYDROXY-9,10-ANTHRAQUINONE-3-CARBOXYLIC ACID;1,8-dihydroxy-3-carboxyanthraquinone
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  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
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  • JR MediChem
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
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  • Usbiological
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  • ManufacturerAK Scientific
  • Product numberC432
  • Product descriptionRhein
  • Packaging1g
  • Price$364
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberH60902
  • Product descriptionRhein, 97%
  • Packaging250mg
  • Price$154.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberH60902
  • Product descriptionRhein, 97%
  • Packaging1g
  • Price$456
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging25mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging100mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging250mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging1g
  • Price$19
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging5g
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging25g
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105483
  • Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
  • Packaging100g
  • Price$548
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0026593
  • Product descriptionRHEIN 95.00%
  • Packaging100MG
  • Price$739.2
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0026593
  • Product descriptionRHEIN 95.00%
  • Packaging1G
  • Price$1871.1
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1810
  • Product descriptionRhein
  • Packaging100mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1810
  • Product descriptionRhein
  • Packaging200mg
  • Price$84
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberN1810
  • Product descriptionRhein
  • Packaging500mg
  • Price$152
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN99157
  • Product descriptionRhein ≥98%
  • Packaging20mg
  • Price$40
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific C432 Rhein 1g $364 2021-12-16 Buy
Alfa Aesar H60902 Rhein, 97% 250mg $154.65 2024-03-01 Buy
Alfa Aesar H60902 Rhein, 97% 1g $456 2024-03-01 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 25mg $5 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 100mg $6 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 250mg $9 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 1g $19 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 5g $58 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 25g $188 2021-12-16 Buy
Ambeed A105483 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+% 100g $548 2021-12-16 Buy
American Custom Chemicals Corporation API0026593 RHEIN 95.00% 100MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation API0026593 RHEIN 95.00% 1G $1871.1 2021-12-16 Buy
ApexBio Technology N1810 Rhein 100mg $53 2021-12-16 Buy
ApexBio Technology N1810 Rhein 200mg $84 2021-12-16 Buy
ApexBio Technology N1810 Rhein 500mg $152 2021-12-16 Buy
Arctom CFN99157 Rhein ≥98% 20mg $40 2021-12-16 Buy

Properties

Melting point :≥300 °C (lit.)
Boiling point :346.72°C (rough estimate)
Density :1.3269 (rough estimate)
refractive index :1.4413 (estimate)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :3.17±0.20(Predicted)
color :Yellow to Dark Orange
Water Solubility :<0.1 g/100 mL at 17 ºC
λmax :432nm(MeOH)(lit.)
Merck :14,8176
BRN :2222155
Stability :Hygroscopic
InChIKey :FCDLCPWAQCPTKC-UHFFFAOYSA-N
LogP :4.290 (est)
CAS DataBase Reference :478-43-3(CAS DataBase Reference)
EPA Substance Registry System :2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (478-43-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α, IL-1β, and HMBG1 expression. Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic β-cell apoptosis. It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.

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