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ChemicalBook >> CAS DataBase List >> CPI-203

CPI-203

CPI-203 price.
  • $49 - $2839
  • Product name: CPI-203
  • CAS: 1446144-04-2
  • MF: C19H18ClN5OS
  • MW: 399.9
  • EINECS:
  • MDL Number:MFCD27997886
  • Synonyms:(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide CPI 203;CPI 203 (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-;(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic amide;CPI203(TEN010,JQ2,RG-6146);6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-;CPI203 (CPI-203)
30 prices
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Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Biorbyt Ltd
  • BroadPharm
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2338AH
  • Product description(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
  • Packaging10mg
  • Price$162
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA639214
  • Product description(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+%
  • Packaging2mg
  • Price$128
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA639214
  • Product description(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+%
  • Packaging5mg
  • Price$179
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA639214
  • Product description(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+%
  • Packaging10mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA639214
  • Product description(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+%
  • Packaging25mg
  • Price$424
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA639214
  • Product description(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+%
  • Packaging100mg
  • Price$937
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1081
  • Product descriptionCPI-203
  • Packaging1mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146235
  • Product descriptionCPI203 (CPI-203) >99%,ee > 99%
  • Packaging100mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146235
  • Product descriptionCPI203 (CPI-203) >99%,ee > 99%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146235
  • Product descriptionCPI203 (CPI-203) >99%,ee > 99%
  • Packaging1g
  • Price$2839
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25351
  • Product descriptionCPI203
  • Packaging50mg
  • Price$525
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25351
  • Product descriptionCPI203
  • Packaging25mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25351
  • Product descriptionCPI203
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15479
  • Product descriptionCPI-203 ≥98%
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15479
  • Product descriptionCPI-203 ≥98%
  • Packaging5mg
  • Price$249
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15479
  • Product descriptionCPI-203 ≥98%
  • Packaging10mg
  • Price$412
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2338AH (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide 10mg $162 2021-12-16 Buy
Ambeed A639214 (S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+% 2mg $128 2021-12-16 Buy
Ambeed A639214 (S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+% 5mg $179 2021-12-16 Buy
Ambeed A639214 (S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+% 10mg $250 2021-12-16 Buy
Ambeed A639214 (S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+% 25mg $424 2021-12-16 Buy
Ambeed A639214 (S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide 99+% 100mg $937 2021-12-16 Buy
ApexBio Technology B1081 CPI-203 1mg $49 2021-12-16 Buy
Biorbyt Ltd orb146235 CPI203 (CPI-203) >99%,ee > 99% 100mg $765 2021-12-16 Buy
Biorbyt Ltd orb146235 CPI203 (CPI-203) >99%,ee > 99% 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb146235 CPI203 (CPI-203) >99%,ee > 99% 1g $2839 2021-12-16 Buy
BroadPharm BP-25351 CPI203 50mg $525 2021-12-16 Buy
BroadPharm BP-25351 CPI203 25mg $350 2021-12-16 Buy
BroadPharm BP-25351 CPI203 10mg $180 2021-12-16 Buy
Cayman Chemical 15479 CPI-203 ≥98% 1mg $57 2024-03-01 Buy
Cayman Chemical 15479 CPI-203 ≥98% 5mg $249 2024-03-01 Buy
Cayman Chemical 15479 CPI-203 ≥98% 10mg $412 2024-03-01 Buy

Properties

Boiling point :690.4±65.0 °C(Predicted)
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :≥40 mg/mL in DMSO; insoluble in H2O; ≥6.1 mg/mL in EtOH with ultrasonic
pka :16.00±0.40(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

(+)-JQ1 binds to the acetyl-lysine recognition pocket of bromodomains 1 and 2 on BRD4 with Kd values of ~50 and 90 nM, respectively. This displaces BRD4 from nuclear chromatin in cells, inducing differentiation and growth arrest in midline carcinoma cells. CPI-203 is a primary amide analog of (+)-JQ1 which has shown superior bioavailability with oral or i.p. administration. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells. CPI-203 arrests the growth of leukemic T cells in vitro (EC50 = 91 nM) and rapidly suppresses leukemia burden in mice.

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