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ChemicalBook >> CAS DataBase List >> I-BET151 (GSK1210151A)

I-BET151 (GSK1210151A)

I-BET151 (GSK1210151A) price.
  • $36 - $3876
  • Product name: I-BET151 (GSK1210151A)
  • CAS: 1300031-49-5
  • MF: C23H21N5O3
  • MW: 415.44
  • EINECS:
  • MDL Number:MFCD22124472
  • Synonyms:7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one;I-BET 151/GSK 1210151A;GSK1210151A (I-BET151);7-(3,5-diMethylisoxazol-4-yl)-8-Methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-iMidazo[4,5-c]quinolin-2(3H)-one;7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2;GSK 1210151A;I-BET 151;7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one I-BET151(GSK1210151A)
29 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX5823
  • Product descriptionGSK1210151A
  • Packaging50mg
  • Price$604
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1500
  • Product descriptionI-BET151(GSK1210151A)
  • Packaging5mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1500
  • Product descriptionI-BET151(GSK1210151A)
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1500
  • Product descriptionI-BET151(GSK1210151A)
  • Packaging50mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1500
  • Product descriptionI-BET151(GSK1210151A)
  • Packaging100mg
  • Price$630
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60281
  • Product descriptionI-BET151(GSK1210151A) ≥98%
  • Packaging10mg
  • Price$278
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146286
  • Product descriptionI-BET151 (GSK1210151A) >98%
  • Packaging100mg
  • Price$1060.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146286
  • Product descriptionI-BET151 (GSK1210151A) >98%
  • Packaging250mg
  • Price$1949.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146286
  • Product descriptionI-BET151 (GSK1210151A) >98%
  • Packaging1g
  • Price$3876
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43075
  • Product descriptionI-BET 151
  • Packaging1mg
  • Price$72.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43075
  • Product descriptionI-BET 151
  • Packaging2mg
  • Price$116
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43075
  • Product descriptionI-BET 151
  • Packaging5mg
  • Price$202
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43075
  • Product descriptionI-BET 151
  • Packaging10mg
  • Price$323
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43075
  • Product descriptionI-BET 151
  • Packaging25mg
  • Price$562.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11181
  • Product descriptionI-BET151 ≥98%
  • Packaging1mg
  • Price$36
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11181
  • Product descriptionI-BET151 ≥98%
  • Packaging5mg
  • Price$98
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X5823 GSK1210151A 50mg $604 2021-12-16 Buy
ApexBio Technology B1500 I-BET151(GSK1210151A) 5mg $96 2021-12-16 Buy
ApexBio Technology B1500 I-BET151(GSK1210151A) 10mg $120 2021-12-16 Buy
ApexBio Technology B1500 I-BET151(GSK1210151A) 50mg $360 2021-12-16 Buy
ApexBio Technology B1500 I-BET151(GSK1210151A) 100mg $630 2021-12-16 Buy
Arctom CFN60281 I-BET151(GSK1210151A) ≥98% 10mg $278 2021-12-16 Buy
Biorbyt Ltd orb146286 I-BET151 (GSK1210151A) >98% 100mg $1060.8 2021-12-16 Buy
Biorbyt Ltd orb146286 I-BET151 (GSK1210151A) >98% 250mg $1949.9 2021-12-16 Buy
Biorbyt Ltd orb146286 I-BET151 (GSK1210151A) >98% 1g $3876 2021-12-16 Buy
Biosynth Carbosynth FD43075 I-BET 151 1mg $72.5 2021-12-16 Buy
Biosynth Carbosynth FD43075 I-BET 151 2mg $116 2021-12-16 Buy
Biosynth Carbosynth FD43075 I-BET 151 5mg $202 2021-12-16 Buy
Biosynth Carbosynth FD43075 I-BET 151 10mg $323 2021-12-16 Buy
Biosynth Carbosynth FD43075 I-BET 151 25mg $562.5 2021-12-16 Buy
Cayman Chemical 11181 I-BET151 ≥98% 1mg $36 2024-03-01 Buy
Cayman Chemical 11181 I-BET151 ≥98% 5mg $98 2024-03-01 Buy

Properties

Density :1.314
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :11.14±0.20(Predicted)
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 μM, respectively. Through this action, it blocks the growth of leukemic cell lines driven by mixed lineage leukemia (MLL) fusions at nanomolar concentrations, whereas tyrosine kinase activated cells were much less sensitive. Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines. I-BET151 is effective in vivo, suppressing MLL leukemia progression in two different mouse models.