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ChemicalBook >> CAS DataBase List >> Bosutinib

Bosutinib

Bosutinib price.
  • $44 - $1167
  • Product name: Bosutinib
  • CAS: 380843-75-4
  • MF: C26H29Cl2N5O3
  • MW: 530.45
  • EINECS:700-455-1
  • MDL Number:MFCD07367846
  • Synonyms:4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile;Bosutinib ( SKI-606 );Bosutinib for research;3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-Methoxyphenyl)aMino]-6-Methoxy-7-[3-(4-Methyl-1-piperazinyl)propoxy]-;Bosutinib(TINIBS );WAY-173606;Bosulif(bosutinib);4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile Bosutinib (SKI-606)
35 prices
Selected condition:
Brand
  • AccelPharmtech
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemcia Scientific
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • Usbiological
Package
  • 20mg
  • 25mg
  • 10
  • 5mg
  • 10mg
  • 2x25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 5g
  • 50
  • 1g
  • 10mM(in 1mL DMSO)
  • 10G
  • ManufacturerAccelPharmtech
  • Product numberAT821010G
  • Product descriptionBosutinib 99.00%
  • Packaging10G
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberA820
  • Product descriptionBosutinib
  • Packaging250mg
  • Price$326
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2149
  • Product descriptionBosutinib(SKI-606)
  • Packaging10mM(in 1mL DMSO)
  • Price$64
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60155
  • Product descriptionBosutinib(SKI-606) ≥98%
  • Packaging20mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2435
  • Product descriptionBosutinib
  • Packaging100mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2435
  • Product descriptionBosutinib
  • Packaging1g
  • Price$375
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1407
  • Product descriptionSKI606-Bosutinib 99%
  • Packaging5mg
  • Price$82.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1407
  • Product descriptionSKI606-Bosutinib 99%
  • Packaging25mg
  • Price$247.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1407
  • Product descriptionSKI606-Bosutinib 99%
  • Packaging2x25mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146277
  • Product descriptionBosutinib (SKI-606) >98%
  • Packaging250mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146277
  • Product descriptionBosutinib (SKI-606) >98%
  • Packaging1g
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19002
  • Product descriptionBosutinib
  • Packaging25mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19002
  • Product descriptionBosutinib
  • Packaging50mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19002
  • Product descriptionBosutinib
  • Packaging100mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19002
  • Product descriptionBosutinib
  • Packaging250mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19002
  • Product descriptionBosutinib
  • Packaging500mg
  • Price$350
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech AT821010G Bosutinib 99.00% 10G $1000 2021-12-16 Buy
AK Scientific A820 Bosutinib 250mg $326 2021-12-16 Buy
ApexBio Technology A2149 Bosutinib(SKI-606) 10mM(in 1mL DMSO) $64 2021-12-16 Buy
Arctom CFN60155 Bosutinib(SKI-606) ≥98% 20mg $168 2021-12-16 Buy
AvaChem 2435 Bosutinib 100mg $65 2021-12-16 Buy
AvaChem 2435 Bosutinib 1g $375 2021-12-16 Buy
Axon Medchem Axon1407 SKI606-Bosutinib 99% 5mg $82.5 2021-12-16 Buy
Axon Medchem Axon1407 SKI606-Bosutinib 99% 25mg $247.5 2021-12-16 Buy
Axon Medchem Axon1407 SKI606-Bosutinib 99% 2x25mg $330 2021-12-16 Buy
Biorbyt Ltd orb146277 Bosutinib (SKI-606) >98% 250mg $510 2021-12-16 Buy
Biorbyt Ltd orb146277 Bosutinib (SKI-606) >98% 1g $765 2021-12-16 Buy
Biosynth Carbosynth FB19002 Bosutinib 25mg $50 2021-12-16 Buy
Biosynth Carbosynth FB19002 Bosutinib 50mg $75 2021-12-16 Buy
Biosynth Carbosynth FB19002 Bosutinib 100mg $120 2021-12-16 Buy
Biosynth Carbosynth FB19002 Bosutinib 250mg $225 2021-12-16 Buy
Biosynth Carbosynth FB19002 Bosutinib 500mg $350 2021-12-16 Buy

Properties

Melting point :116-120 ºC
Boiling point :649.7±55.0 °C(Predicted)
Density :1.36
vapor pressure :0-0Pa at 20℃
storage temp. :room temp
solubility :DMSO: ≥15mg/mL
pka :7.63±0.10(Predicted)
form :powder
color :off-white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :PICKMQXYAMDEPF-UHFFFAOYSA-N
LogP :3.3-4.3 at pH9.5
Surface tension :72.4mN/m at 3.6mg/L and 20℃
CAS DataBase Reference :380843-75-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The non-receptor tyrosine kinases c-Src and Abl have important roles in cell signaling and cancer. Bosutinib is best known as a potent dual inhibitor of c-Src and Abl (IC50 = 1.2 and 1.0 nM, respectively). Consistent with this action, bosutinib can be effective in regulating tumor growth and differentiation. Bosutinib is best known as a potent dual inhibitor of c-Src and Abl (IC50 = 1.2 and 1.0 nM, respectively). Consistent with this action, bosutinib can be effective in regulating tumor growth and differentiation. Bosutinib also inhibits, at nanomolar concentrations, other members of the Src family (e.g., Yes, Fgr, Lck, Fyn), as well as members of the TEC family, and certain other kinases. These actions extend the usefulness of this compound to cancers beyond those involving Src and Abl.

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