(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
![(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol price.](/CAS/GIF/779353-01-4.gif)
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- $28 - $3728.1
- Product name: (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
- CAS: 779353-01-4
- MF: C21H28N6O2
- MW: 396.49
- EINECS:214-589-6
- MDL Number:MFCD16037702
- Synonyms:(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Dinaciclib (SCH727965);2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-;Dinaciclib, >=98%;DINACICLIB (SCH727965);SCH 727965;(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol;(S)-3-(((3-Ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methy;PS-095760;(S)-3-((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyriMidin-7-ylaMino)Methyl)pyridine 1-oxide
28 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Medical Isotopes, Inc.
- Tocris
- TRC
- Usbiological
Package
- 10mg
- 25mg
- 10
- 1unit
- 5MG
- 10mM(in 1mL DMSO)
- 50mg
- 100mg
- 250mg
- 1000mg
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000811
- Product descriptionDINACICLIB 95.00%
- Packaging5MG
- Price$206.8
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8412
- Product descriptionDinaciclib(SCH727965)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8412
- Product descriptionDinaciclib(SCH727965)
- Packaging10mM(in 1mL DMSO)
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8412
- Product descriptionDinaciclib(SCH727965)
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8412
- Product descriptionDinaciclib(SCH727965)
- Packaging25mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8412
- Product descriptionDinaciclib(SCH727965)
- Packaging50mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60205
- Product descriptionDinaciclib(SCH727965) ≥98%
- Packaging10mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1776
- Product descriptionSCH727965-Dinaciclib 99%
- Packaging25mg
- Price$341
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180976
- Product descriptionDinaciclib (SCH727965) >98%
- Packaging100mg
- Price$1133.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180976
- Product descriptionDinaciclib (SCH727965) >98%
- Packaging250mg
- Price$1949.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180976
- Product descriptionDinaciclib (SCH727965) >98%
- Packaging1000mg
- Price$3728.1
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD158760
- Product descriptionDinaciclib
- Packaging25mg
- Price$525
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD158760
- Product descriptionDinaciclib
- Packaging50mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14707
- Product descriptionDinaciclib ≥98%
- Packaging5mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14707
- Product descriptionDinaciclib ≥98%
- Packaging10mg
- Price$176
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14707
- Product descriptionDinaciclib ≥98%
- Packaging25mg
- Price$412
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | KIN0000811 | DINACICLIB 95.00% | 5MG | $206.8 | 2021-12-16 | Buy |
| ApexBio Technology | A8412 | Dinaciclib(SCH727965) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A8412 | Dinaciclib(SCH727965) | 10mM(in 1mL DMSO) | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A8412 | Dinaciclib(SCH727965) | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A8412 | Dinaciclib(SCH727965) | 25mg | $330 | 2021-12-16 | Buy |
| ApexBio Technology | A8412 | Dinaciclib(SCH727965) | 50mg | $470 | 2021-12-16 | Buy |
| Arctom | CFN60205 | Dinaciclib(SCH727965) ≥98% | 10mg | $288 | 2021-12-16 | Buy |
| Axon Medchem | Axon1776 | SCH727965-Dinaciclib 99% | 25mg | $341 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180976 | Dinaciclib (SCH727965) >98% | 100mg | $1133.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180976 | Dinaciclib (SCH727965) >98% | 250mg | $1949.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180976 | Dinaciclib (SCH727965) >98% | 1000mg | $3728.1 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD158760 | Dinaciclib | 25mg | $525 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD158760 | Dinaciclib | 50mg | $800 | 2021-12-16 | Buy |
| Cayman Chemical | 14707 | Dinaciclib ≥98% | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 14707 | Dinaciclib ≥98% | 10mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 14707 | Dinaciclib ≥98% | 25mg | $412 | 2024-03-01 | Buy |
Properties
Melting point :>78oC (dec.)
Density :1.33
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :15.15±0.10(Predicted)
form :Solid
color :White to Light Beige
Stability :Hygroscopic
CAS DataBase Reference :779353-01-4
Density :1.33
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :15.15±0.10(Predicted)
form :Solid
color :White to Light Beige
Stability :Hygroscopic
CAS DataBase Reference :779353-01-4
Safety Information
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Description
Cyclin-dependent kinases (CDKs) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. Dinaciclib inhibits CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC50 values of 3, 1, 1, and 4 nM, respectively. Compared to the pan-CDK inhibitor flavopiridol , dinaciclib is an equally potent inhibitor of CDK1 and CDK9 but a 12-14-fold more potent inhibitor of CDK2 and CDK5. It has been shown to inhibit DNA synthesis by blocking thymidine incorporation in A2780 ovarian cancer cells with an IC50 value of 4 nM. At 5 mg/kg it prevents tumor growth by 50% in an A2780 ovarian carcinoma mouse xenograft model and is active against a broad spectrum of human tumor cell lines in vitro (IC50s = 7-17 nM).More related product prices
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Suppliers and manufacturers
career henan chemical co
![(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol](https://img.chemicalbook.com/ProductImageEN/2019-7/small/a5b4d703-7dc0-4232-9cae-87441080794d.png)
$1.00 /1KG
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol CAS:779353-01-4
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol CAS:779353-01-4
Shaanxi Dideu Medichem Co. Ltd
![(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol](/ProductImageEN/2021-04/small/236f30b8-faec-456a-b187-a54cb47af23c.png)
ATK CHEMICAL COMPANY LIMITED
Changzhou PBpharmaceutical R&D Co.,Ltd
Hubei xin bonus chemical co. LTD
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
Zhejiang J&C Biological Technology Co.,Limited
$1.10 /1g
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol CAS:779353-01-4
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol CAS:779353-01-4