4-formyl-3-methoxybenzonitrile
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4-formyl-3-methoxybenzonitrile ??
- ???
- 109-111℃
- ?? ?
- 318℃
- ??
- 1.18
- ???
- 0.003-2.3Pa at 20-80℃
- ???
- 138℃
- ?? ??
- under inert gas (nitrogen or Argon) at 2-8°C
- InChI
- InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3
- InChIKey
- ZXENVSJZOHXCKL-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(C=O)C(OC)=C1
- LogP
- 1.42 at 20℃ and pH7
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
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4-formyl-3-methoxybenzonitrile C??? ??, ??, ??
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4-formyl-3-methoxybenzonitrile is a Finerenone intermediate compound. Finerenone is a non-steroidal salicorticosteroid receptor antagonist used to reduce the risk of serious kidney and heart problems in patients with chronic kidney disease associated with type 2 diabetes.Synthesis
79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde (4-formyl-3-methoxybenzonitrile) is obtained as a white solid.
4-formyl-3-methoxybenzonitrile ?? ?? ? ???
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Benzonitrile, 4-(hydroxymethyl)-3-methoxy-
????????,4-???-2-???-(9Cl)
????????,3-???-4-??-(9CI)
3-Methoxy-4-methylbenzoic acid
4-DibroMo??-3-????????
4-Bromo-2-hydroxybenzoic acid
3-Iodophenol
2-HYDROXY-4-IODO-BENZALDEHYDE
3-???4-???????
4-Iodo-2-methoxybenzaldehyde
4-????-3-????????
4-???-2-?????????
??4-???-2-????????98
?? ??
4-formyl-3-methoxybenzonitrile ?? ??
???( 327)?? ??
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