4-formyl-3-methoxybenzonitrile
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- CAS-Nr.
- 21962-45-8
- Englisch Name:
- 4-formyl-3-methoxybenzonitrile
- Synonyma:
- 4-forMyl-3-Methoxybenzonitrile;4-Cyaon-2-methoxybenzaldehyde;Finerenone Impurity 111;2-Methoxy-4-cyanobenzaldehyde;4-CYANO-2-METHOXYBENZALDEHYDE;4-Cyan0-2-methoxybenzaldehyde;4-Formyl-3-methoxybenzonitril;3-Formyl-3-methoxybenzonitrile;Benzonitrile, 4-formyl-3-methoxy-;Para-tert-Butyl Benzene Sulfonamide
- CBNumber:
- CB8684633
- Summenformel:
- C9H7NO2
- Molgewicht:
- 161.16
- MOL-Datei:
- 21962-45-8.mol
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4-formyl-3-methoxybenzonitrile Eigenschaften
- Schmelzpunkt:
- 109-111℃
- Siedepunkt:
- 318℃
- Dichte
- 1.18
- Dampfdruck
- 0.003-2.3Pa at 20-80℃
- Flammpunkt:
- 138℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- InChI
- InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3
- InChIKey
- ZXENVSJZOHXCKL-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(C=O)C(OC)=C1
- LogP
- 1.42 at 20℃ and pH7
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
43 |
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| S-S?tze: |
36/37 |
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| HS Code |
2926907090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P280, P305+P351+P338, P310 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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4-formyl-3-methoxybenzonitrile Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
4-formyl-3-methoxybenzonitrile is a Finerenone intermediate compound. Finerenone is a non-steroidal salicorticosteroid receptor antagonist used to reduce the risk of serious kidney and heart problems in patients with chronic kidney disease associated with type 2 diabetes.
Synthese
79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde (4-formyl-3-methoxybenzonitrile) is obtained as a white solid.
4-formyl-3-methoxybenzonitrile Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-formyl-3-methoxybenzonitrile Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 322)Lieferanten
21962-45-8()Verwandte Suche:
- 4-CYANO-2-METHOXYBENZALDEHYDE
- 2-Methoxy-4-cyanobenzaldehyde
- 4-ForMyl-3-Methoxybenzonitrile(2-Methoxy-4-cyanobenzaldehyde)
- Benzonitrile, 4-formyl-3-methoxy-
- 4-Cyaon-2-methoxybenzaldehyde
- 4-forMyl-3-Methoxybenzonitrile
- 4-Formyl-3-methoxybenzonitrile (or)
4-Cyano-2-Methoxy Benzaldehyde
- 4-Cyano-2-neneneba methoxy Benzaldehyde
- 4-Cyan0-2-methoxybenzaldehyde
- 4-CYANO-2-METHOXYBENZALDEHYDE,Finerenone
- 3-Formyl-3-methoxybenzonitrile
- 4-Formyl-3-methoxybenzonitril
- Para-tert-Butyl Benzene Sulfonamide
- Finerenone Impurity 111
- 21962-45-8
- Intermediate
- 21962-45-8
