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ZLN005

ZLN005 ??? ???
?? ??:
49671-76-3
???:
ZLN005
???(??):
ZLN005;CS-1004;ZLN005, >=98%;ZLN 005; ZLN-005;ZLN005, 10 mM in DMSO;2-(4-tert-Butylphenyl)benzimidazole;2-(4-tert-Butylphenyl)-1H-benzimidazole;2-(4-TERT-BUTYLPHENYL)-1H-BENZO[D]IMIDAZOLE;ZLN005, PGC-1alpha transcriptional activator;2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole
CBNumber:
CB82681122
???:
C17H18N2
??? ??:
250.34
MOL ??:
49671-76-3.mol
MSDS ??:
SDS

ZLN005 ??

???
257-258℃
?? ?
415.3±38.0 °C(Predicted)
??
1.102±0.06 g/cm3(Predicted)
?? ??
Sealed in dry,Store in freezer, under -20°C
???
DMSO: ???10mg/mL, ??
?? ?? (pKa)
11.52±0.10(Predicted)
??? ??
??
??
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 22-36
????? 26
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H413 ??? ??? ?? ????? ??? ??? ?? ?? ????? ?? - ?? ?? 4
??????:
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
2 0

ZLN005 C??? ??, ??, ??

??

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.

??

ZLN005 increaces PGC-1α and downstream gene transcription in skeletal muscles and increases fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice.

ZLN005 ?? ?? ? ???

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ZLN005 ?? ??

???( 136)?? ??
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ZLN005 ?? ??:

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