ZLN005
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- CAS-Nr.
- 49671-76-3
- Englisch Name:
- ZLN005
- Synonyma:
- ZLN005;CS-1004;ZLN005, >=98%;ZLN 005; ZLN-005;2-(4-tert-Butylphenyl)benzimidazole;2-(4-tert-Butylphenyl)-1H-benzimidazole;2-(4-TERT-BUTYLPHENYL)-1H-BENZO[D]IMIDAZOLE;2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole;1H-Benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-;2-(4-tert-Butylphenyl)benzimidazole ZLN005
- CBNumber:
- CB82681122
- Summenformel:
- C17H18N2
- Molgewicht:
- 250.34
- MOL-Datei:
- 49671-76-3.mol
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ZLN005 Eigenschaften
- Schmelzpunkt:
- 257-258℃
- Siedepunkt:
- 415.3±38.0 °C(Predicted)
- Dichte
- 1.102±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- DMSO: soluble10mg/mL, clear
- pka
- 11.52±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
ZLN005 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Peroxisome proliferator-
activated receptor-
γ coactivator-
1α (PGC-
1α) is a tissue-
specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates the expression of PGC-
1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. Chronic administration of 15 mg/kg/day ZLN005 to diabetic
db/db mice increased PGC-
1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.
Verwenden
ZLN005 increaces PGC-1α and downstream gene transcription in skeletal muscles and increases fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice.
ZLN005 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ZLN005 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 119)Lieferanten
49671-76-3()Verwandte Suche:
- 2-(4-TERT-BUTYLPHENYL)-1H-BENZO[D]IMIDAZOLE
- 2-(4-tert-Butylphenyl)-1H-benzimidazole
- 2-(4-tert-Butylphenyl)benzimidazole
- ZLN005, >=98%
- 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole
- 2-(4-tert-Butylphenyl)benzimidazole ZLN005
- ZLN005 2-(4-tert-Butylphenyl)benzimidazole
- ZLN005
- CS-1004
- ZLN 005; ZLN-005
- 1H-Benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-
- 49671-76-3
- Inhibitors
