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D(+)-???????

D(+)-???????
D(+)-??????? ??? ???
?? ??:
112709-60-1
???:
D(+)-???????
???(??):
D(+)-???????
???:
D(+)-VESAMICOL HYDROCHLORIDE
???(??):
D(+)-VESAMICOL HCL;1s-trans-cyclohexano;D(+)-VESAMICOL HYDROCHLORIDE;D-(+)-Vesamicol hydrochloride;(1S,2S)-2-(4-Phenyl-1-piperidinyl)cyclohexanol;Cyclohexanol, 2-(4-phenyl-1-piperidinyl)-, (1S,2S)-
CBNumber:
CB8222190
???:
C17H25NO
??? ??:
259.39
MOL ??:
112709-60-1.mol
MSDS ??:
SDS

D(+)-??????? ??

?? ?
393.5±42.0 °C(Predicted)
??
1.086±0.06 g/cm3(Predicted)
???
DMSO: ??? ? ??
?? ?? (pKa)
15.16±0.40(Predicted)
??? ??
??
??? ??
??? ??
??
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??

??? ?? Xn
?? ???? ?? 20/21/22
????? 36
WGK ?? 3
RTECS ?? GW0765070

D(+)-??????? C??? ??, ??, ??

??

D-(+)-Vesamicol hydrochloride can be used as a reactant to prepare:
  • Trialkylstannyl vesamicol analogs as potent vesicular acetylcholine transporters (VAChTs) and sigma receptors.
  • Vesamicol analog, (+)-2-[4-(4-iodophenyl)piperidino] cyclohexanol as a possible tumor imaging agent.

?? ??

D-(+)-Vesamicol is a potent inhibitor of acetycholine transport into the synaptic vesicles in cholinergic nerve terminals. It is 25-times less potent than the L-form.

Biochem/physiol Actions

Less active enantiomer of vesamicol

D(+)-??????? ?? ?? ? ???

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D(+)-??????? ?? ??

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