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2-?????????

2-?????????
2-????????? ??? ???
?? ??:
6850-38-0
???:
2-?????????
???(??):
2-?????????
???:
2-Aminocyclohexanol
???(??):
aminocyclohexanol;2-Aminocyclohexanol;TIMTEC-BB SBB004300;2-Aminocyclohenxanol;Cyclohexanol, 2-aMino-;2-Aminocyclohexanol98%;2-Aminocyclohexanol 98%;2-AMinocyclohexanol 2-Aminocyclohexan-1-ol98%;2-AMINOHYDROXYCYCLOHEXANE
CBNumber:
CB3445286
???:
C6H13NO
??? ??:
115.17
MOL ??:
6850-38-0.mol

2-????????? ??

???
65 °C
?? ?
212 °C
??
1.037±0.06 g/cm3(Predicted)
?? ??
Keep in dark place,Inert atmosphere,Room temperature
???
???? ???
??? ??
powder to crystal
?? ?? (pKa)
14.94±0.40(Predicted)
??
White to Light orange to Yellow
InChIKey
PQMCFTMVQORYJC-UHFFFAOYSA-N
CAS ??????
6850-38-0(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi,Xn
?? ???? ?? 34-22
????? 26-36/37/39
????(UN No.) 3259
?? ?? ?? Irritant
?? ?? 8
???? III
HS ?? 2922190090
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H314 ??? ?? ??? ?? ??? ??? ????? ?? ????? ?? 1A, B, C ?? GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
??????:
P260 ??·?·??·???·??·...·????? ???? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

2-????????? C??? ??, ??, ??

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White to Light orange to Yellow powder to crystal.

??

Trans-2-aminocyclohexanol and cis-/trans-1,2-cyclohexanediamines have found their application in the synthesis of the antiarrhythmic medicament vernakalant and spleen tyrosine kinase inhibitor, κ-opioid analgesics.

?? ??

2-Aminocyclohexanol Synthesis: Under water bath reaction conditions, 214.3 g of ammonia water was added to a 500 mL three-necked flask. Stir and heat, and when the internal temperature reaches about 50°C, start to slowly drop 50.0 g of 1,2-epoxycyclohexane into the reaction flask. After the dropwise addition was completed, the reaction was performed at a constant temperature for 12h. After the reaction was completed, the reaction was processed to obtain a crude product, which was purified by recrystallization to obtain 2-aminocyclohexanol with a yield of 90% and an amine value (mgKOH/g) of 453.

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