?????
|
|
????? ??
- ???
- 230-232°C
- ?? ?
- 363.32°C (rough estimate)
- ??
- 1.2514 (rough estimate)
- ???
- -4 ° (C=1.8, EtOH)
- ?? ??
- Inert atmosphere,Room Temperature
- ???
- DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 7.49±0.40(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ???? ?? ???
- ???
- ?(??), ?? ??? ? ???(50mg/ml)? ?????.
- Merck
- 14,4670
- BRN
- 309850
- InChIKey
- AIONOLUJZLIMTK-AWEZNQCLSA-N
- LogP
- 2.90
- CAS ??????
- 520-33-2(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36/37/39-27-37 | ||
| WGK ?? | 3 | ||
| HS ?? | 29329990 |
????? C??? ??, ??, ??
??
Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.??? ??
Beige to Light Brown Crystalline Solid??
(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.??
ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).Purification Methods
Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]????? ?? ?? ? ???
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?? ??
????? ?? ??
???( 446)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +86-18374838656 |
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????? ?? ??:
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HESPERETIN-7-NEOHESPERIDOSIDE hplc,Neohesperidin，Hesperetin 7-neohesperidoside,HESPERETIN-7-NEOHESPERIDOSIDE,HESPERETIN-7-O-NEOHESPERIDOSIDE
Paeoniflorin
Naringin
(+/-)-HESPERETIN,HESPERETIN
HESPERETIN LAURATE
4'-METHOXYFLAVANONE
4'-METHOXYFLAVANONE
hesperetin 5-O-glucoside
HESPERETIN, [3H(G)]
HESPERETIN CHALCONE
HESPERETIN DIHYDROCHALCONE
HESPERETIN DIHYDROCHALCONE(RG)