Anpirtoline hydrochloride C??? ??, ??, ??

Originator

Anpirtoline Hydrochloride,YQBio (Shanghai) Co. Ltd.

Manufacturing Process

2-Chloro-6-(4-piperidinylthio)pyridine:
The reaction is carried out under an argon atmosphere. 0.27 g of 80% sodium hydride (0.009 mol) are suspended in 10 ml of dimethylacetamide; the mixture is cooled with ice and then 0.615 g (0.004 mol) of solid 4- mercaptopiperidine hydrochloride are added and stirred for 10 minutes. A solution of 0.588 g (0.004 mol) of 2,6-dichloropyridine in 5 ml of dimethylacetamide are then added dropwise to this mixture and the reaction mixture is stirred for 2.5 hours at room temperature.
Working up of the reaction mixture: 25 ml of water are added dropwise with cooling, 20 ml of methylene chloride are then added, the organic phase is separated off, the aqueous phase is then extracted twice with 15 ml of methylene chloride each time, the combined organic phase is washed twice, in each case with 10 ml of water, dried with sodium sulfate, the solution is concentrated on a rotary evaporator, the residue is mixed with 10 ml of absolute ethanol and then reconcentrated.
The product which is obtained on removal of the eluant is diluted with 10 ml of ether, an equivalent quantity of HCl in isopropanol is added dropwise and the mixture is placed for several hours in a deep freezer after addition of seed crystals. The hydrochloride of the 2-chloro-6-(4-piperidinylthio)pyridine which crystallizes out is filtered off with suction, washed with ether and dried under oil pump vacuum at 50°C. Melting point of the hydrochloride 132°-133°C.

Therapeutic Function

Analgesic, Antidepressant

Anpirtoline hydrochloride ?? ?? ? ???

???

?? ??

Anpirtoline hydrochloride ?? ??

???	??	???	??	?? ?	??
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
BOC Sciences	--	info@bocsci.com	USA	0	65
Shanghai Haohong Pharmaceutical Co., Ltd.	4008210725 4008210725	malulu@leyan.com	China	54987	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8617	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24644	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5098	58

Anpirtoline hydrochloride ?? ??: