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99614-02-5
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???(??):
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Ondansetron
???(??):
ONDANSETRON HCL;ONDANSETRON HYDROCHLORIDE DIHYDRATE;ONDANSETRON HCL DIHYDRATE;Ondanestron;Yatrox;gr38032;gr38032x;Ondanles;GR 38032F;HSDB 6544
CBNumber:
CB6340203
???:
C18H19N3O
??? ??:
293.36
MOL ??:
99614-02-5.mol
MSDS ??:
SDS

????? ??

???
231-232°
?? ?
435.21°C (rough estimate)
??
1.1385 (rough estimate)
???
1.5855 (estimate)
?? ??
−20°C
???
H2O: >5 mg/mL
??? ??
??
??? ??
??? ??
?? ?? (pKa)
pKa 7.4 (Uncertain)
??
???
CAS ??????
99614-02-5(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T,Xi
?? ???? ?? 25-36/37/38
????? 45-37/39-26
????(UN No.) UN 2811 6.1/PG 3
WGK ?? 3
RTECS ?? FE6375500
HS ?? 29339900
?? ?? ??? 99614-02-5(Hazardous Substances Data)
?? TDLo vn-man: 229 mg/kg/I LANCAO 344,190,94
????(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H318 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P280, P305+P351+P338, P310
H410 ??? ??? ?? ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
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P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P273 ???? ???? ???.
P280 ????/???/???/?????? ?????.
P391 ???? ????.
NFPA 704
3
0 0

????? MSDS


Ondansetron

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Ondansetron (hydrochloride) (CRM) (Item No. 21710) is a certified reference material categorized as an antiemetic. Formulations containing ondansetron have been used to reduce alcohol consumption and mood disturbances in early-onset alcoholics. This product is intended for research and forensic applications.

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White to yellow crystal

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antibacterial

Indications

Ondansetron (Zofran) is potent antagonists of 5-HT3 receptors,which is found peripherally on vagal nerve terminals and centrally in the CTZ. During chemotherapy that induces vomiting, mucosal enterochromaffin cells in the GI tract release serotonin, which stimulates 5-HT3 receptors.

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This causes vagal afferent discharge, inducing vomiting. In binding to 5-HT3 receptors, ondansetron blocks serotonin stimulation, hence vomiting, after emetogenic stimuli such as cisplatin. Headache is the most frequently reported adverse effect of these medications.

Safety Profile

A poison by intravenous route.Human systemic effects by intravenous route: jaundice.When heated to decomposition it emits toxic vapors ofNOx.

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Lithium tert-butoxide Ondansetron hydrochloride dihydrate 2-Bromoaniline Para-??????? ?????? ????? 2-?????? 1,3-???????? ??????? ????? ??? ?? ?? 1,2,3,4-?????????? ??? ??????

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