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4?????????
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?? ??:
82413-23-8
???:
4?????????
???(??):
4?????????
???:
4Hydroxy Tamoxifen
???(??):
4’-hydroxy Tamoxifen;4'-Hydroxy TaMoxifen (contains up to 10% E isoMer);Tamoxifen Citrate Impurity 13 (4'-Hydroxytamoxifen);4-[(1Z)-1-[[4-[2-(Dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]phenol;Phenol, 4-[(1Z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-
CBNumber:
CB41175806
???:
C26H29NO2
??? ??:
387.51
MOL ??:
82413-23-8.mol

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150-153°C
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514.4±50.0 °C(Predicted)
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1.092±0.06 g/cm3(Predicted)
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Amber Vial, -20°C Freezer, Under Inert Atmosphere
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?? ?? (pKa)
10.32±0.15(Predicted)
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4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen , a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity. With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. At 10-100 μM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines.

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White Solid

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A metabolite of Tamoxifen (T006000).

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