Cetirizine
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Cetirizine ??
- ???
- 110-115°C
- ?? ?
- 542.1±45.0 °C(Predicted)
- ??
- 1.237±0.06 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- insoluble in EtOH; ≥122 mg/mL in H2O; ≥19.44 mg/mL in DMSO
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 3.46±0.10(Predicted)
- ??
- Off-white to light yellow
- ???
- 101mg/L
- CAS ??????
- 83881-51-0(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| WGK ?? | 3 | ||
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| RTECS ?? | AG0977500 | ||
| ?? ?? ??? | 83881-51-0(Hazardous Substances Data) |
| ????(GHS): |
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Cetirizine C??? ??, ??, ??
??? ??
white, crystalline powder??
Cetirizine is a metabolite of the first-generation H1 antihistamine hydroxyzine. A reduced dosage (5 mg daily) is recommended in patients with chronic renal or hepatic impairment. Sedative side effects increase with dosages of cetirizine >10 mg per day.??
ChEBI: A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.?? ??
Cetirizine, (±)-[2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetic acid (Zyrtec), is a racemic compound available as a white crystalline powder that is water soluble. Cetirizine is the primary acid metabolite of hydroxyzine, resulting from complete oxidation of the primary alcohol moiety. This compound is zwitterionic and relatively polar and thus does not penetrate or accumulate in the CNS. Before its introduction in the United States, cetirizine was one of the most widely prescribed H1-antihistamines in Europe.Cetirizine is indicated for the temporary relief of runny nose, sneezing, itching of the nose or throat, and/or itchy, watery eyes caused by hay fever or other upper respiratory allergies. It also relieves itching caused by hives (urticaria), but it will not prevent hives or an allergic skin reaction from occurring.
Clinical Use
Cetirizine, the acid metabolite from oxidation of the primary alcohol of the antihistamine hydroxyzine, is a widely used antihistamine. It has a long duration of action and is highly selective for H1 receptors. No cardiotoxicity has been reported, but some drowsiness occurs.Cetirizine ?? ?? ? ???
???
???????
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[2-(2,2-diethoxyethoxy)ethyl]-
????? ?????
Cetirizine dihydrochloride
2-[2-[4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]ethanol hydrochloride
4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE
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Cetirizine ?? ??
???( 214)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085 +86-15531157085 |
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| career henan chemical co | +86-0371-86658258 +8613203830695 |
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Cetirizine ?? ??:
?? ?? ???? ??? ????? 2,2-???????? ?????? ???? ?? ???????? N-?????? ???????
acetic acid, triethoxy-, ethyl ester
Methyl 2,2-dimethylphenylacetate
Chlorodimethylphenylsilane
Loratadine
Ebastine
Levoceitrizine Hcl
Cetirizine-d4
Cetirizine dihydrochloride
CETIRIZINE DIHYDROCHLORIDE MM(CRM STANDARD),CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD)
Levocetirizine dihydrochloride
CETIRIZINE N-OXIDE