Cetirizine
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- CAS-Nr.
- 83881-51-0
- Englisch Name:
- Cetirizine
- Synonyma:
- CETIRIZINE LACTOSE ESTER;vidix;P-071;Zyrlex;Zirtek;Reactine;Formistin;Ceterizine;CETIRIZINE;CETIRIZINE BASE
- CBNumber:
- CB3440625
- Summenformel:
- C21H25ClN2O3
- Molgewicht:
- 388.89
- MOL-Datei:
- 83881-51-0.mol
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Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Cetirizine Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
white, crystalline powder
Verwenden
Cetirizine is a metabolite of the first-generation H1 antihistamine hydroxyzine. A reduced dosage (5 mg daily) is recommended in patients with chronic renal or hepatic impairment. Sedative side effects increase with dosages of cetirizine >10 mg per day.
Definition
ChEBI: A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
Allgemeine Beschreibung
Cetirizine, (±)-[2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetic acid (Zyrtec), is a racemic compound available as a white crystalline powder that is water soluble. Cetirizine is the primary acid metabolite of hydroxyzine, resulting from complete oxidation of the primary alcohol moiety. This compound is zwitterionic and relatively polar and thus does not penetrate or accumulate in the CNS. Before its introduction in the United States, cetirizine was one of the most widely prescribed H1-antihistamines in Europe.
Cetirizine is indicated for the temporary relief of runny nose, sneezing, itching of the nose or throat, and/or itchy, watery eyes caused by hay fever or other upper respiratory allergies. It also relieves itching caused by hives (urticaria), but it will not prevent hives or an allergic skin reaction from occurring.
Clinical Use
Cetirizine, the acid metabolite from oxidation of the primary alcohol of the antihistamine
hydroxyzine, is a widely used antihistamine. It has a long
duration of action and is highly selective for H1 receptors. No cardiotoxicity has been
reported, but some drowsiness occurs.
Cetirizine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cetirizine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 213)Lieferanten
83881-51-0()Verwandte Suche:
- 2-[2-[4-(4-Chlorobenzhydryl)-1-piperazinyl]ethoxy]acetic acid
- 2-[4-(4-Chlorobenzhydryl)-1-piperazinyl]ethoxyacetic acid
- 5-[4-[(4-Chlorophenyl)phenylmethyl]piperazino]-3-oxapentanoic acid
- Ceterizine
- Cetirizine DISCONTINUED (Replaced with C1876)
- 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)Methyl]piperazin-1-yl}ethoxy)acetic acid
- vidix
- Zirtek
- Zyrlex
- (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-aceticaci
- (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticacid
- CETIRIZINE
- (2-(4-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZIN-1-YL)-ETHOXY)-ACETIC ACID
- Cetirizine Hydrochloride BP
- Cetirizine (Cetrizine) Di HCl
- CERTIRIZINE 2HCL
- CETIRIZINE IMPURITY A(RS)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE EPC(CRM STANDARD)
- Cetrizinehydrochloride
- (RS)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
- 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid
- Formistin
- P-071
- Reactine
- Cetirizine(EP/BP)
- Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
- Cetirizine USP/EP/BP
- CETERIZINE DIHYDROCHLORIDE
- Cetirizine
DISCONTINUED, offer C281100
- Cetirizine Imp(unknown)(pure)
- Cetirizine DIHCL- EP/IP/USP/Ph. Eur
- CETIRIZINE LACTOSE ESTER
- 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid[Cetirizine
- (2-(4-((4-Chlorophenyl)phenylmethyl)piperazin-1-yl)ethoxy)-aceticaci
- Cetirizine Hydrochloride API
- CETIRIZINE BASE
- 83881-51-0
- C21H25ClN2O32HCl
