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Oxiracetam

Oxiracetam ??? ???
?? ??:
62613-82-5
???:
Oxiracetam
???(??):
4-hydroxy-2-oxo-1-pyrrolidineacetamid;2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide;ct-848;isf2522;Neurome;Olaxitam;Olacetam;Neuractiv;CGP 21690;oxiraceta
CBNumber:
CB3328242
???:
C6H10N2O3
??? ??:
158.16
MOL ??:
62613-82-5.mol

Oxiracetam ??

???
165-168 °C
?? ?
494.6±40.0 °C(Predicted)
??
1.416
?? ??
Sealed in dry,Room Temperature
???
DMSO (Slightly, Heated), Methanol (Slightly, Heated)
?? ?? (pKa)
13.76±0.20(Predicted)
??? ??
??
??? ??
??? ??
??
???? ?????
Merck
14,6942
InChI
InChI=1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)
InChIKey
IHLAQQPQKRMGSS-UHFFFAOYSA-N
SMILES
N1(CC(N)=O)CC(O)CC1=O
CAS ??????
62613-82-5(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/38
????? 26-36
WGK ?? 3
RTECS ?? UX9656638
HS ?? 2933.79.8500
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321 (…) ??? ???.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P362 ??? ??? ?? ?? ?? ?????
NFPA 704
0
2 0

Oxiracetam MSDS


4-Hydroxy-2-oxopyrrolidine-N-acetamide

Oxiracetam C??? ??, ??, ??

??

Oxiracetam is a structural analogue of piracetam. This compound has enhancing effects on vigilance and memory. In comparison with piracetam, oxiracetam exhibits greater improvement in memory (Itil et al., 1986) and has been used extensively for the treatment of dementia, including AD, VaD, MID (Baumel et al., 1989; Dysken et al., 1989), and mixed forms. Green et al. (1992) failed to demonstrate a difference from placebo in AD patients. In contrast, Maina et al. (1989) studied 289 patients with MID in a double-blind placebo-controlled trial and after 12 weeks of treatment found that oxiracetam reduced behavioural symptoms.

??? ??

Whie Solid

??

Oxiracetam is a 4-hydroxy analog of piracetam with psychostimulant activity, reportedly useful in relieving the symptoms of cerebral insufficiency in the elderly.

Purification Methods

This nootropic (Alzheimer) drug is purified by recrystallisation from MeOH or aqueous Me2CO and dried in vacuo. [NMR, IR: Pifferi & Pinza Farmaco Ed Sci 32 602 1977, Banfi et al. Farmaco Ed Sci 39 16 1984, Gouilaev & Senning Brain Research Rev 19 180 1994.]

Oxiracetam ?? ?? ? ???

???

???, ??? ??? 2-?????????????? ????? Anhydrous benzene 1,1-?????? ?????? ????????????

?? ??

Oxiracetam ?? ??

???( 549)?? ??
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Oxiracetam ?? ??:

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