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NG-25

NG-25 ??? ???
?? ??:
1315355-93-1
???:
NG-25
???(??):
NG25;3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide;NG-25;NG 25; NG-25;HG-7-92-01 (NG 25);NG25, 10 mM in DMSO;NG-25 ISO 9001：2015 REACH;NG25,MAP kinase kinase kinase, MEKK, MAPKKK,NG 25,NG-25,MAP4K,inhibit,Inhibitor,MAP3K,MAPK Kinase Kinase Kinase;N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide;N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
CBNumber:
CB22645146
???:
C29H30F3N5O2
??? ??:
537.58
MOL ??:
1315355-93-1.mol
MSDS ??:
SDS

NG-25 ??

??
1.313±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
DMSO? ???
??? ??
??
?? ?? (pKa)
12.91±0.70(Predicted)
??
???? ????
???
H2O: 5mg/mL, clear
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(UN No.) UN 2811 6.1 / PGIII
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H413 ??? ??? ?? ????? ??? ??? ?? ?? ????? ?? - ?? ?? 4
??????:
P273 ???? ???? ???.

NG-25 C??? ??, ??, ??

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NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity.

Biochem/physiol Actions

NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

NG-25 ?? ?? ? ???

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NG-25 ?? ??

???( 82)?? ??
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NG-25 ?? ??:

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