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ChemicalBook >> CAS DataBase List >>NG-25

NG-25

CAS No.
1315355-93-1
Chemical Name:
NG-25
Synonyms
NG25;3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide;NG-25;NG 25; NG-25;HG-7-92-01 (NG 25);NG-25 ISO 9001：2015 REACH;NG25,MAP kinase kinase kinase, MEKK, MAPKKK,NG 25,NG-25,MAP4K,inhibit,Inhibitor,MAP3K,MAPK Kinase Kinase Kinase;N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide;N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide;Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-
CBNumber:
CB22645146
Molecular Formula:
C29H30F3N5O2
Molecular Weight:
537.58
MDL Number:
MFCD19443255
MOL File:
1315355-93-1.mol
MSDS File:
SDS
Last updated:2024-11-18 17:01:59

NG-25 Properties

Density 1.313±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO
form powder
pka 12.91±0.70(Predicted)
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H413
Precautionary statements  P273-P301+P310+P330
RIDADR  UN 2811 6.1 / PGIII

NG-25 price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1332 NG25 trihydrochloride ≥98% (HPLC) 1315355-93-1 5MG $169 2023-06-20 Buy
Sigma-Aldrich SML1332 NG25 trihydrochloride ≥98% (HPLC) 1315355-93-1 25MG $676 2023-06-20 Buy
Tocris 5429 NG25 ≥98%(HPLC) 1315355-93-1 5 $325 2021-12-16 Buy
TRC N393510 NG25 1315355-93-1 1mg $85 2021-12-16 Buy
ChemScene CS-0875 NG25 99.35% 1315355-93-1 1mg $96 2021-12-16 Buy
Product number Packaging Price Buy
SML1332 5MG $169 Buy
SML1332 25MG $676 Buy
5429 5 $325 Buy
N393510 1mg $85 Buy
CS-0875 1mg $96 Buy

NG-25 Chemical Properties,Uses,Production

Uses

NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity.

Biochem/physiol Actions

NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

storage

Store at -20°C

NG-25 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 71)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32080 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38470 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 8752 58

View Lastest Price from NG-25 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NG25 pictures 2024-11-18 NG25
1315355-93-1
 US $79.00-263.00 / mg ≥95% 10g TargetMol Chemicals Inc.
  • NG25 pictures
  • NG25
    1315355-93-1
  • US $79.00-263.00 / mg
  • ≥95%
  • TargetMol Chemicals Inc.

NG-25 Spectrum

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide 3-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3v-(trifluoromethyl)phenyl)-4-methylbenzamide NG-25 HG-7-92-01 (NG 25) N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide NG 25; NG-25 Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)- NG-25 ISO 9001：2015 REACH NG25 3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide NG25,MAP kinase kinase kinase, MEKK, MAPKKK,NG 25,NG-25,MAP4K,inhibit,Inhibitor,MAP3K,MAPK Kinase Kinase Kinase 1315355-93-1 C29H30F3N5O2 Smad TGF-beta TGF-beta/Smad