Leonurine hydrochloride
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Leonurine hydrochloride ??
- ???
- 238 °C
- ?? ?
- 496.7±55.0 °C(Predicted)
- ??
- 1.29±0.1 g/cm3(Predicted)
- ?? ??
- Keep in dark place,Inert atmosphere,2-8°C
- ???
- DMSO: ???2mg/mL, ??(??)
- ?? ?? (pKa)
- 8.26±0.25(Predicted)
- ??? ??
- ??
- ??
- ???? ????
- ???
- ??? ?? ?????? 1? ?? ??????. DMSO? ???? -20°C?? ?? 1?? ?? ??? ? ????.
- InChIKey
- WNGSUWLDMZFYNZ-UHFFFAOYSA-N
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
Leonurine hydrochloride C??? ??, ??, ??
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An amorphous alkaloid, leonurine has been obtained from the leaves of Leonurus sibiricus L. and is characterized as the crystalline hydrochloride hydra te, m.p. 19l-4°C. Hydrolysis yields syringic acid and Q-hydroxybutylguanidine. The total synthesis of the alkaloid has been achieved, confirming the above structure.??
Leonurine is a pseudoalkaloid that has been isolated from Leonotis leonurus. A natural product with antioxidant, anti-inflammatory and cardioprotective properties for the treatment of wild variety of conditions including stroke, cerebral thrombosis and cardiovascular diseases.?? ??
Kubota, Nakajima., Nippon Yakubusugaku Zasshi., 163 (1930)Goto et al., Tetrahedron Lett., 545 (1962)
Total synthesis:
Kishi et al., Tetrahedron Lett., 637 (1968)
Leonurine hydrochloride ?? ?? ? ???
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Leonurine hydrochloride ?? ??
???( 296)?? ??
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