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125-33-7
???:
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???(??):
????;????
???:
Primidone
???(??):
Cyral;Sertan;roe101;Midone;Roe 101;Mizodin;Mizolin;Mysedon;Misoline;Mizoline
CBNumber:
CB1161900
???:
C12H14N2O2
??? ??:
218.25
MOL ??:
125-33-7.mol
MSDS ??:
SDS

???? ??

???
281-282°C
?? ?
358.94°C (rough estimate)
??
1.1402 (rough estimate)
???
1.6660 (estimate)
???
9℃
?? ??
Sealed in dry,Room Temperature
???
??? ?? ?? ????, ????? ?? ?????(96%). ???? ??? ?????.
??? ??
Solid
?? ?? (pKa)
12.26±0.40(Predicted)
??
???? ?????
???
19ºC?? <0.1g/100mL
Merck
14,7746
BCS Class
2
InChIKey
DQMZLTXERSFNPB-UHFFFAOYSA-N
CAS ??????
125-33-7(CAS DataBase Reference)
NIST
Primidone(125-33-7)
IARC
2B (Vol. 108) 2016
EPA
Primidone (125-33-7)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn,T,F
?? ???? ?? 22-40-39/23/24/25-23/24/25-11
????? 22-36-45-36/37-16-7
????(UN No.) 3249
WGK ?? 3
RTECS ?? UV9100000
?? ?? 6.1(b)
???? III
HS ?? 29335990
?? ?? ??? 125-33-7(Hazardous Substances Data)
?? child,TDLo,oral,625mg/kg (625mg/kg),BEHAVIORAL: SLEEPBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: GENERAL ANESTHETIC,British Medical Journal. Vol. 1, Pg. 90, 1957.
???? ?? KE-13609
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H351 ?? ??? ??? ??? (????? ?? ???? ???? ???? ??? ?? ????? ??? ???? ??) ??? ?? ?? 2 ?? P201, P202, P281, P308+P313, P405,P501
??????:
P201 ?? ? ?? ???? ?????.
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
NFPA 704
0
2 0

???? MSDS


Primidone

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Primidone is chemically and structurally similar to phenobarbital with the exception that the carbonyl group on C2 is replaced by a methylene group. This modification leads to the production of a drug with strong anticonvulsant properties without expressed soporific effects.

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Crystalline Solid

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Primidone is mainly used for major attacks.

??

ChEBI: A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.

?? ??

Odorless white crystalline powder. Slightly bitter taste. No acidic properties.

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Insoluble in water.

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Primidone is an amide. May react with azo and diazo compounds to generate toxic gases. May react with strong reducing agents to form flammable gases. A very weak base. The Combustion generates toxic mixed oxides of nitrogen (NOx).

????

Flash point data for Primidone are not available; however, Primidone is probably combustible.

???? ??

Anticonvulsant.

Clinical Use

Primidone is the 2-deoxy derivative of phenobarbital and is approved by the U.S. FDA for initial or adjunctive treatment of simple partial, complex partial, and tonic-clonic seizures. It is less effective against these types of seizures than is phenytoin or CBZ, and it shares the antiseizure and sedative actions of phenobarbital. Although not approved for the purpose, it often is used to treat benign familial tremor (essential tremor).

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As with phenobarbital, serious toxicity for primidone is rare, although it may cause disabling sedation, irritability, and decreased mental functioning in a number of persons. Ataxia, dysphoria, idiosyncratic rash, leukopenia, agranulocytosis, lymphadenopathy, hepatitis, and a systemic lupus erythematosus–like syndrome have been reported adverse effects for primidone. Deficiencies of folic acid and of vitamins D and K are possible with long-term therapy of primidone, as is a folateresponsive megaloblastic anemia. Measurement of the complete blood cell count should be performed at 6-month intervals.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human teratogenic effects include developmental abnormalities of the craniofacial area, skin and skin appendages, and cardlovascular system. Human reproductive effects: effects on newborn, including unusual growth statistics, drug dependence, physical and other neonatal changes. Experimental teratogenic and reproductive effects. Human mutation data reported. An addictive drug. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES.

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