Entecavir
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Entecavir ??
- ???
- 249-252°C
- ?? ?
- 661.4±65.0 °C(Predicted)
- ??
- 1.81±0.1 g/cm3(Predicted)
- ?? ??
- -20°C
- ???
- DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 14.22±0.60(Predicted)
- ??? ??
- ??
- ??
- ???? ????
- optical activity
- [α]/D +25 to +40°, c = 0.2 in H2O
- ???
- H2O: 0.5mg/mL, clear (warmed)
- ???
- ???
- CAS ??????
- 142217-69-4(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????? | 24/25 | ||
|---|---|---|---|
| WGK ?? | 3 | ||
| HS ?? | 29339900 | ||
| ?? ?? ??? | 142217-69-4(Hazardous Substances Data) |
| ????(GHS): |
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| ?? ?: | Warning | |||||||||||||||||||||||||||||||||||
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Entecavir C??? ??, ??, ??
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Entecavir is a cyclopentyl guanosine analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection, and it is the third nucleoside or nucleotide analog to be marketed for this indication. Lamivudine, a deoxythiacytosine analog, and adefovir dipivoxil, a nucleotide analog, have been marketed since 1998 and 2002, respectively. Entecavir and adefovir are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections.??? ??
White to Off-White/Yellow Crystalline Powder??
ChEBI: Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it ha no activity against HIV. It is used for the treatment of chronic hepatitis B.???
Baraclude (BMS)Clinical Use
Treatment of chronic hepatitis B virus infection in patients >16 years of age.Entecavir comes as a tablet and solution (liquid) to take by mouth. It is usually taken once a day on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal. Take entecavir at around the same time every day.
Entecavir ?? ?? ? ???
???
6H-Purin-6-one, 9-[(1S,3R,4S)-4-(acetyloxy)-2-methylene-3-[[(4-nitrobenzoyl)oxy]methyl]cyclopentyl]-2-amino-1,9-dihydro-
Cyclopentanemethanol, 5-(acetyloxy)-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylene-, 1-acetate, (1R,3S,5S)-
?? ??
Entecavir ?? ??
???( 528)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9306 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 988 | 58 |
| Wuhan Golt Biotech Co., Ltd. | +8615389281203 |
maria@goltbiotech.com | China | 970 | 58 |
| Shenzhen Monkono Technology Co.,Ltd | +86-17063441314 |
sansbiotech@outlook.com | China | 677 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085 +86-15531157085 |
abby@chuanghaibio.com | China | 8809 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 997 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 |
niki@zlchemi.com | China | 3720 | 58 |
| Hebei Junhua Import and Export Co., LTD | +86-18503288844 +86-18503288844 |
junhua1@hb-junhua.com | China | 977 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29730 | 60 |
Entecavir ?? ??:
??????? 6-??? ???? ??? 2-??????? ?????? ??? ??? ?????? ???? ???????? ???(???????)????? ???(???????)????? ??? ??????????????? ????
entecavir hydrate,ENTECAVIR MONOHYDRATE
methylol cellulose
CHLOROPHOSPHONAZO III
ALTRENOGEST
Entacapone
Docetaxel
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one