Theaflavin 3,3′-digallate
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Theaflavin 3,3′-digallate ??
- ???
- 226～230℃
- ?? ?
- 1352.6±65.0 °C(Predicted)
- ??
- 1.97±0.1 g/cm3(Predicted)
- ?? ??
- Store at -20°C, sealed storage, away from moisture and light
- ???
- DMSO : 41.67 mg/mL (47.97 mM; Need ultrasonic)
- ??? ??
- Solid
- ?? ?? (pKa)
- 6.55±0.20(Predicted)
- ??
- ?? ???
- InChIKey
- ZEASWHWETFMWCV-ISBUVJFSSA-N
- CAS ??????
- 30462-35-2
??
| WGK ?? | 3 | ||
|---|---|---|---|
| HS ?? | 29329990 |
Theaflavin 3,3′-digallate C??? ??, ??, ??
??
Theaflavin-3,3''-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities. It has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively). It also reduces hydroxyl radical-induced damage to plasmid DNA. TFDG (12.5-50 μM) prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells. In vivo, TFDG reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner.??
Theaflavin 3,3''-Digallate has been found to be an inhibitor against human pancreatic α-Amylase.Theaflavin 3,3′-digallate ?? ?? ? ???
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Theaflavin 3,3′-digallate ?? ??
???( 156)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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Theaflavin 3,3′-digallate ?? ??:
??? ??????? ????? ????
Theaflavin
Methyl gallate
THEAFLAVINE-3,3'-DIGALLATE
THEAFLAVINE-3-GALLATE
THEAFLAVIN 3'-O-GALLATE
1,3,6-TRI-O-GALLOYL-B-D-GLUCOSE
(-)-Epigallocatechin
Punicalagin
(-)-EGCG-3''-O-ME
6-Shogaol
8-O-acetyl shanzhiside methyl ester
YUNACONITINE
lithospermic acid
10-GINGEROL
cis-(±)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol