アンピシリン 化學(xué)特性,用途語,生産方法
外観
白色?わずかにうすい黃色, 粉末
溶解性
水にやや溶けにくく、アセトンに溶けにくく、エタノール(95)に極めて溶けにくい。
解説
アンピシリンは，抗生物質(zhì)の一つ．ペニシリングループの一種で，グラム陽性菌にも陰性菌にも広い抗菌効果を示す．
用途
アンピシリン（Ampicillin）とは、1961年から感染癥の治療に用いられているβ-ラクタム系抗生物質(zhì)の1種である。アミノペニシリングループに屬し、抗菌スペクトルや活性はアモキシシリンとほぼ同じである。
効能
抗生物質(zhì), 細胞壁合成阻害薬
説明
Ampicillin is an antibacterial antibiotic from the α-aminobenzyl penicillin group, which differs from penicillin by the presence of an amino group that facilitates penetration through the outer membrane of some gram-negative bacteria.
Ampicillin is Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria.
Ampicillin is a β-lactam antibiotic within the penicillin family. As a member of this family, Ampicillin is susceptible to β-lactamase, which hydrolyzes the β-lactam ring. This broad spectrum antibiotic is effective against gram-positive, gram-negative bacteria and anaerobic bacteria. Ampicillin is widely used in cell culture as a selective agent. As an antibiotic, Ampicillin binds to penicillin binding proteins (PBPs) on a susceptible organism and Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. After binding to the PBPs, Ampicilin acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and thereby prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.
Ampicillin sodium can be used as a selective agent in several types of isolation media. Ampicillin sodium is routinely used to select for cells containing the pcDNA3.1 and pEAK10 resistance plasmids in cell line A904L at an effective concentration of 50 μg/ml.
化學(xué)的特性
Ampicillin in anhydrous form occurs as
crystals.
使用
Labelled Ampicillin. Orally active, semi-synthetic antibiotic; structurally related to penicillin. Antibacterial.
定義
ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.
一般的な説明
Ampicillin was synthesized by Beecham Research Laboratories in 1961 and evaluated for its anti-gram-negative activity by Rolinson et al.. It was the first semisynthetic penicillin showing strong activity against gramnegative bacilli. Although it is hydrolyzed by bacterial penicillinase, it is active against Escherichia coli, Shigella, Proteus mirabilis, and Haemophilus influenzae and is used very widely as an oral antibiotic. Ampicillin also is used by injection for serious infections.
接觸アレルゲン
Ampicillin caused contact dermatitis in a nurse also
sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin)
and in a pharmaceutical factory
worker. Systemic drug reactions are common. Crossreactivity
is regular with ampicillin and can occur with
other penicillins.
安全性プロファイル
Poison by intracerebral route. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: fever, agranulocytosis, and other blood effects. An experimental teratogen. Mutation data reported. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NO, and SOx,.
職業(yè)ばく露
Used as an antibiotic.
輸送方法
UN3077 Environmentally hazardous substances,
solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous
material, Technical Name Required.
不和合性
May be incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from alkaline materials, strong
bases, strong acids, oxoacids, epoxides.
廃棄物の処理
It is inappropriate and possibly
dangerous to the environment to dispose of expired or waste
pharmaceuticals by flushing them down the toilet
or discarding them to the trash. Household quantities of
expired or waste pharmaceuticals may be mixed with wet cat
litter or coffee grounds, double-bagged in plastic, discard in
trash. Larger quantities shall carefully take into consideration
applicable DEA, EPA, and FDA regulations. If possible return
the pharmaceutical to the manufacturer for proper disposal
being careful to properly label and securely package the material.
Alternatively, the waste pharmaceutical shall be labeled,
securely packaged and transported by a state licensed medical
waste contractor to dispose by burial in a licensed hazardous
or toxic waste landfill or incinerator.
アンピシリン 上流と下流の製品情報
原材料
準備製品