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ChemicalBook >> CAS DataBase List >>(R,R)-Formoterol

(R,R)-Formoterol

CAS No.
67346-49-0
Chemical Name:
(R,R)-Formoterol
Synonyms
Arformoterol;(R,R)-Formoterol;Arformoterol 13D3;Formoterol Impurity 10;(R,R)-Formoterol Impurity;(R,R)-Formoterol (Arformoterol);(R,R)-Formoterol Impurity Tartrate;(-)-FORMOTEROL; ARFORMOTEROL; FORMOTEROL;Formoterol Impurity 10（(R,R)-Formoterol）(Arformoterol);4-[(1R)-2-[[(1R)-2-(4-Methoxyphenyl)-1-methylethyl]amino]-1-hydroxyethyl]-2-(formylamino)phenol
CBNumber:
CB81237087
Molecular Formula:
C19H24N2O4
Molecular Weight:
344.4
MDL Number:
MFCD00864141
MOL File:
67346-49-0.mol
MSDS File:
SDS
Last updated:2024-07-02 08:55:17

(R,R)-Formoterol Properties

Melting point 73-75 °C
Boiling point 603.2±55.0 °C(Predicted)
Density 1.233±0.06 g/cm3(Predicted)
solubility 25℃: DMSO
form Powder
pka 8.95±0.50(Predicted)
color White to off-white
FDA UNII F91H02EBWT

(R,R)-Formoterol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0009091 ARFORMOTEROL 95.00% 67346-49-0 10MG $224.7 2021-12-16 Buy
Product number Packaging Price Buy
API0009091 10MG $224.7 Buy

(R,R)-Formoterol Chemical Properties,Uses,Production

Description

Arformoterol, a selective long-acting b2-agonist, was launched as an inhalation solution for treatment of bronchoconstriction associated with COPD. It is the active (R,R)-enantiomer of the previously marketed b2-agonist formoterol, which is registered as a racemic mixture. Similar to other b2-agonists, the mechanism of action of formoterol and arformoterol involves activation of adenyl cyclase, leading to increased production of cyclic adenosine monophosphate (cAMP) via ATP. Increased levels of intracellular cAMP result in relaxation of the bronchial smooth muscle, and also prevent mast cells from releasing inflammatory mediators. Arformoterol has high binding affinity for the human b2 receptor (Kd 2.9 nM) and approximately 39-fold selectivity over the b1 receptor (Kd 113 nM). It is W1,000 times more potent b2 ligand than the corresponding (S,S)-enantiomer (Kd 3100 nM), and twice as potent as racemic formoterol (Kd 5.2 nM). Additionally, arformoterol acts as a full or nearly full agonist of the b2 receptor, whereas the (S,S)-enantiomer acts as an inverse agonist. Therefore, the (R,R)-enantiomer may account exclusively for the activation of b2 receptors by the racemic mixture.

Originator

Sepracor (US)

Uses

(R,R)-Formoterol (Arformoterol) (CAS# 67346-49-0) is aused in the methods for treating chronic obstructive pulmonary disease by administration of a bronchodilator using a nebulizer.

Uses

Anti-asthmatic and bronchodilator.

Definition

ChEBI: An N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have R configuration. The active enantiomer of formoterol, it is administered by inhalation generally as the tartrate salt) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).

brand name

Brovana

(R,R)-Formoterol Preparation Products And Raw materials

Raw materials

Preparation Products

(R,R)-Formoterol Suppliers

Global( 69)Suppliers
Supplier Tel Email Country ProdList Advantage
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 10983 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Shandong Risen-Sun Pharmaceutical Co., Ltd 		+86-15552509998 +86-15621883869 liutf@jewim.com.cn China 251 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11922 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Shanghai Hanhong Scientific Co., Ltd. 		+undefined17612118332 Lucky@hanhonggroup.com China 6035 58

View Lastest Price from (R,R)-Formoterol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R,R)-Formoterol pictures 2025-04-22 (R,R)-Formoterol
67346-49-0
 US $70.00-700.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
  • (R,R)-Formoterol pictures
  • (R,R)-Formoterol
    67346-49-0
  • US $70.00-700.00 / kg
  • 0.99
  • Zibo Hangyu Biotechnology Development Co., Ltd
N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide 4-[(1R)-2-[[(1R)-2-(4-Methoxyphenyl)-1-methylethyl]amino]-1-hydroxyethyl]-2-(formylamino)phenol N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(αR)-α-methyl-4-methoxyphenethyl]amino]ethyl]phenyl]formamide N-[2-Hydroxy-5-[(R)-1-hydroxy-2-[[(R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]- Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, [R-(R*,R*)]- Arformoterol (R,R)-Formoterol Arformoterol 13D3 (-)-FORMOTEROL; ARFORMOTEROL; FORMOTEROL (R,R)-Formoterol (Arformoterol) Formoterol Impurity 10 Formoterol Impurity 10（(R,R)-Formoterol）(Arformoterol) ArformoterolQ: What is Arformoterol Q: What is the CAS Number of Arformoterol Q: What is the storage condition of Arformoterol N-[2-hydroxy-5-[(1RS) - 1-hydroxy-2-[[(1RS) - 2 - (4-methoxyphenyl) - 1-methylethyl] amino] ethyl] phenyl] formamide (R,R)-Formoterol Impurity (R,R)-Formoterol Impurity Tartrate N-(2-hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)(methyl)amino)ethyl)phenyl)formamide 67346-49-0