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ChemicalBook >> CAS DataBase List >>Formoterol

Formoterol

CAS No.
73573-87-2
Chemical Name:
Formoterol
Synonyms
FORMOTEROL TARTRATE;Oxis;FORMOTEROL;Formoteral;Eformoterol;FormoterolBase;1-nitrotridec-1-ene;Formoterol Standard;FORMOTEROL TARTARATE;Formoterol USP/EP/BP
CBNumber:
CB7722411
Molecular Formula:
C19H24N2O4
Molecular Weight:
344.4
MDL Number:
MFCD05662345
MOL File:
73573-87-2.mol
Last updated:2024-03-19 15:37:50

Formoterol Properties

Boiling point 603.2±55.0 °C(Predicted)
Density 1.233±0.06 g/cm3(Predicted)
solubility DMSO: 20 mg/mL, soluble
form solid
pka 8.95±0.50(Predicted)
color off-white
Stability Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 73573-87-2(CAS DataBase Reference)
FDA UNII 5ZZ84GCW8B
ATC code R03AC13

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H362-H361
Precautionary statements  P201-P260-P263-P264-P270-P308+P313-P201-P202-P281-P308+P313-P405-P501
WGK Germany  3
Hazardous Substances Data 73573-87-2(Hazardous Substances Data)

Formoterol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Medical Isotopes, Inc. CD33990 Formoterol-13C-d3 73573-87-2 1mg $660 2021-12-16 Buy
American Custom Chemicals Corporation CHM0034798 FORMOTEROL TARTRATE 95.00% 73573-87-2 100MG $885.31 2021-12-16 Buy
AvaChem 2256B Formoterol 73573-87-2 1g $980 2021-12-16 Buy
AvaChem 2256B Formoterol 73573-87-2 100mg $269 2021-12-16 Buy
Product number Packaging Price Buy
CD33990 1mg $660 Buy
CHM0034798 100MG $885.31 Buy
2256B 1g $980 Buy
2256B 100mg $269 Buy

Formoterol Chemical Properties,Uses,Production

Description

Formoterol is a potent bronchoselective β-agonist with long duration of action given by inhalation.

Chemical Properties

solid

Uses

Labeled Formoterol, intended for use as an internal standard for the quantification of Formoterol by GC- or LC-mass spectrometry.

Uses

Formoterol is a useful compound for treating respiratory obstructive diseases.

Definition

ChEBI: A phenylethanoloamine having 4-hydroxy and 3-formamido substituents on the phenyl ring and an N-(4-methoxyphenyl)propan-2-yl substituent.

brand name

Foradil (Novartis).

General Description

Formoterol (Foradil) isalso a lipophilic (log P= 1.6) and long-acting β2-agonist. Ithas 3'-formylamino ( β-directing) and 4 OH groups on onephenyl ring and a lipophilic -directing N-isopropyl-pmethoxyphenylgroup on the nitrogen atom. Its long DOA(12 hours), which is comparable to that of salmeterol, hasbeen suggested to result from its association with the membranelipid bilayer, from which it gradually diffuses to provideprolonged stimulation of β2 receptors and its resistanceto MAO and COMT. Formoterol has a much faster onset ofaction than does salmeterol as result of its lower lipophilicity.Both of these long-acting drugs are used by inhalationand are recommended for maintenance treatment of asthma,usually in conjunction with an inhaled corticosteroid.

Mechanism of action

Formoterol has 3′-formylamino and 4′-hydroxy ring R3 substitution pattern but also an alkoxyphenylethyl lipophilic group R1 on the nitrogen, similar to ritodrine. Although it is less lipophilic (log P = 1.6) than salmeterol, it has a 12-hour duration of action similar to that for salmeterol. It is administered as an inhaled dry powder, because it is unstable to heat and moisture. It is a mixture of (R,R)-(–)- and (S,S)-(+)-stereoisomers, with the (R,R)-isomer having approximately 1,000-fold more affinity for the β2-receptor than the (S,S)-isomer. Because of its high potency and low dose, however, there is no clinical advantage for using (R,R)-formoterol as bronchodilator compared to the racemate. Unlike salmeterol, formoterol has a faster onset of action as a result of its lower lipophilicity. It is also more potent; a 12-μg dose of formoterol has been demonstrated to be equivalent to a 50-μg dose of salmeterol.

Global( 109)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29879 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8618959220845 sales@amoychem.com China 6383 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15352 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9725 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Shanghai Quedan biology science and technology co., ltd 		+86-13004146052 lnzc@quedan.com.cn China 1022 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49977 58

View Lastest Price from Formoterol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-[2-Hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide pictures 2019-07-06 N-[2-Hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide
73573-87-2
 US $1.00 / kg 1kg 99% Customized Career Henan Chemical Co
n-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide FORMOTEROL TARTARATE FormoterolBase Formoterol Fumarate 43229-80-7 / Base Eformoterol Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, rel- Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)- Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-(+-)- Oxis N-[2-Hydroxy-5-[1(R)-hydroxy-2-[[2-(4-methoxyphenyl)-1(R)-methylethyl] amino]ethyl]phenyl]formamide FORMOTEROL rel-N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-Methoxyphenyl)propan-2-yl)aMino)ethyl)phenyl)forMaMide N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide 1-nitrotridec-1-ene Formoterol USP/EP/BP Formoterol (10mM in DMSO) Formoteral FORMOTEROL TARTRATE Formoterol Standard 73573-87-2 C19H24N2O4 Other APIs Inhibitors (intermediates of formoterol ) API