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ChemicalBook >> CAS DataBase List >>SPIPERONE

SPIPERONE

CAS No.
749-02-0
Chemical Name:
SPIPERONE
Synonyms
r5147;Spiperon;SPIPERONE;Spiropitan;Luopenglong;SPIROPERIDOL;Spiperone-d5;SpiperoneHCl;Spiroperidone;Spiperone, 10 mM in DMSO
CBNumber:
CB5748844
Molecular Formula:
C23H26FN3O2
Molecular Weight:
395.47
MDL Number:
MFCD00055099
MOL File:
749-02-0.mol
MSDS File:
SDS
Last updated:2025-05-06 19:49:42

SPIPERONE Properties

Melting point 190-193.60C
Boiling point 630.6±55.0 °C(Predicted)
Density 1.1714 (estimate)
storage temp. Store at RT
solubility H2O: slightly soluble0.2mg/mL
pka pKa 8.31 (Uncertain);9.09 (Uncertain)
form solid
color light yellow
Water Solubility 32mg/L(22 ºC)
FDA UNII 4X6E73CJ0Q
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361
Precautionary statements  P201-P301+P312+P330-P308+P313
Hazard Codes  Xn
Risk Statements  22-63
Safety Statements  36/37
WGK Germany  3
RTECS  XX8925000

SPIPERONE price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S7395 Spiperone solid 749-02-0 250mg $159 2024-03-01 Buy
TRC S682000 Spiperone 749-02-0 25mg $85 2021-12-16 Buy
American Custom Chemicals Corporation API0004229 SPIPERONE 95.00% 749-02-0 10MG $407 2021-12-16 Buy
American Custom Chemicals Corporation API0004229 SPIPERONE 95.00% 749-02-0 50MG $435 2021-12-16 Buy
American Custom Chemicals Corporation API0004229 SPIPERONE 95.00% 749-02-0 100MG $470 2021-12-16 Buy
Product number Packaging Price Buy
S7395 250mg $159 Buy
S682000 25mg $85 Buy
API0004229 10MG $407 Buy
API0004229 50MG $435 Buy
API0004229 100MG $470 Buy

SPIPERONE Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Originator

Spiropitan,Eisai,Japan,1969

Uses

antibacterial

Uses

Spiperone is an antipsychotic.

Definition

ChEBI: An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.

Manufacturing Process

A mixture of 4-carbamoyl-4-N-anilinopiperidine and formamide is heated for 12 hours at 170°C. After cooling, the reaction mixture is divided between 100parts water and 900 parts chloroform. The organic layer is separated, dried over MgSO4 filtered and the filtrate is evaporated. The semisolid residue is stirred in ethyl acetate. The undissolved part is filtered off, washed with ethyl acetate, and dried, yielding 1-oxo-4-phenyl-2,4,8- triazaspiro[4.5]decane.
A mixture of 3.2 parts 4-chloro-p-fluoro-butyrophenone, 3.5 parts 1-oxo-4- phenyl-2,4,8-triazaspiro(4,5)decane, 2 parts Na2CO3 and 0.1 part KI in 200 parts hexone is refluxed with stirring for 50 hours. The mixture is cooled to room temperature, 200 parts water are added and the layers are separated. The organic layer is dried over 10 parts MgSO4, filtered and the solvent removed under reduced pressure on the water bath. The residue is treated with 50 parts diisopropylether. The precipitate is filtered on a Buchner filter and recrystallized from 20 parts hexone at room temperature. The solid is filtered off and dried to yield 1-oxo-4-phenyl-8-[3-(4-fluorobenzoyl)-propyl] -2,4,8- triazaspiro(4.5)decane, melting point 190° to 193.6°C, as a light brown amorphous powder.

brand name

Spiropitan (Janssen Pharmaceutica, Belgium).

Therapeutic Function

Tranquilizer

General Description

Spiperone is a butyrophenone antipsychotic agent. It induces calcium-dependent chloride secretion in the airway and functions as a potential therapeutic target for cystic fibrosis.

Biological Activity

5-HT 2A serotonin and selective D 2 -like dopamine receptor antagonist (K i values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively). Antipsychotic.

Biochem/physiol Actions

Selective D2 dopamine receptor antagonist; α1B-adrenoceptor antagonist; mixed 5-HT2A/5-HT1 serotonin receptor antagonist; antipsychotic.

SPIPERONE Preparation Products And Raw materials

SPIPERONE Suppliers

Global( 66)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32265 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38659 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		027-88013699 17354350817 Ryan@jiutian-bio.com China 6000 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3512 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jk.info@jkchemical.com China 96815 76

View Lastest Price from SPIPERONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Spiperone pictures 2025-05-06 Spiperone
749-02-0
 US $39.00-92.00 / mg 99.83% 10g TargetMol Chemicals Inc.
Spiperone pictures 2025-05-06 Spiperone
749-02-0
 US $39.00-92.00 / mg 99.83% 10g TargetMol Chemicals Inc.
Spiperone pictures 2025-05-01 Spiperone
749-02-0
 US $39.00-92.00 / mg 99.83% 10g TargetMol Chemicals Inc.
  • Spiperone pictures
  • Spiperone
    749-02-0
  • US $39.00-92.00 / mg
  • 99.83%
  • TargetMol Chemicals Inc.
  • Spiperone pictures
  • Spiperone
    749-02-0
  • US $39.00-92.00 / mg
  • 99.83%
  • TargetMol Chemicals Inc.
  • Spiperone pictures
  • Spiperone
    749-02-0
  • US $39.00-92.00 / mg
  • 99.83%
  • TargetMol Chemicals Inc.

SPIPERONE Spectrum

1,3,8-triazaspiro(4.5)decan-4-one,8-(4-(4-fluorophenyl)-4-oxobutyl)-1-phenyl 4’-fluoro-4-(4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)decan-8-yl)-butyrophenon Spiperone-d5 8-(3-p-fluorobenzoyl-1-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)decane 8-triazaspiro(4.5)decan-4-one,8-(3-(p-fluorobenzoyl)propyl)-1-phenyl-3 r5147 8-[3-(P-FLUOROBENZOYL)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE 4-PHENYL-8-[3-(4-FLUOROBENZOYL)-PROPYL]-1-OXO-2,4,8-TRIAZASPIRO[4,5]DECANE SPIPERONE SPIROPERIDOL R 5147, Spiroperidol, 8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one SpiperoneHCl 8-[4-(4-Fluprophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one Spiroperidone Spiropitan 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one 8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Spiperon ethyl4-(4-methoxy-3-methylphenyl)-2,8-dioxobutanoate Serotonin Receptor,pharmacological,Spiperone,inhibit,neurology diseases,5-HT Receptor,5-HT1A,5-HT2A,5-hydroxytryptamine Receptor,dopamine D2,Inhibitor,Dopamine Receptor Luopenglong Spiperone, 10 mM in DMSO 749-02-0 C23H26FN3O2HCl C23H26FN3O2 Serotonin receptor Amine Aromatics Heterocycles ILOSONE Intermediates & Fine Chemicals Pharmaceuticals