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ChemicalBook >> CAS DataBase List >>CONGLOBATIN

CONGLOBATIN

CAS No.
72263-05-9
Chemical Name:
CONGLOBATIN
Synonyms
NGLOBATIN;FW-04-806;CONGLOBATIN;Conglobactin;Conglobatin, >=99%;Conglobatin (FW-04-806);(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione;1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (3E,5R,7S,8S,11E,13R,15S,16S)-;(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis[(1,3-oxazol-5-yl)methyl]-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
CBNumber:
CB3460272
Molecular Formula:
C28H38N2O6
Molecular Weight:
498.61
MDL Number:
MFCD01730317
MOL File:
72263-05-9.mol
MSDS File:
SDS
Last updated:2025-04-28 21:36:36

CONGLOBATIN Properties

Density 1.060±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. -20°C
solubility DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form White to off-white solid.
color White to off-white
UNSPSC Code 12352205
NACRES NA.25

SAFETY

Risk and Safety Statements

WGK Germany  3
HS Code  29419000

CONGLOBATIN price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SMB00017 Conglobatin ≥90% (LC/MS-ELSD) 72263-05-9 1mg $418 2024-03-01 Buy
Cayman Chemical 21766 Conglobatin ≥98% 72263-05-9 500μg $203 2024-03-01 Buy
Cayman Chemical 21766 Conglobatin ≥98% 72263-05-9 2.5mg $914 2024-03-01 Buy
Usbiological C7852-52 Conglobatin 72263-05-9 500ug $482 2021-12-16 Buy
Biorbyt Ltd orb546129 Conglobatin >98% 72263-05-9 1mg $554.2 2021-12-16 Buy
Product number Packaging Price Buy
SMB00017 1mg $418 Buy
21766 500μg $203 Buy
21766 2.5mg $914 Buy
C7852-52 500ug $482 Buy
orb546129 1mg $554.2 Buy

CONGLOBATIN Chemical Properties,Uses,Production

Uses

Conglobatin is a macrolide dilactone from Streptomyces. It exhibits anticancer and immunosuppressant properties.

Uses

Isolated from Streptomyces conglobatus, conglobatin has a unusual, dimeric, macrolide dilactone structure with pendant oxazole groups. Conglobatin exhibits an IC50 of 0.63 μg/ml in a NFAT-dependant transcription assay. No toxicity was observed at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.

in vivo

Conglobatin (50-200 mg/kg; i.g. q3d for 24 d) inhibits the tumor growth of SKBR3 and MCF-7 human breast cancer xenograft models in a dose-dependent manner[2].
Conglobatin (4-8 mg/kg; i.p. daily for 21 days) inhibits tumor growth in EC109 and KYSE510 tumor xenograft models with low toxicity[3]

Animal Model:BALB/c (nu/nu) athymic mice with SKBR3 and MCF-7 tumor xenograft[2]
Dosage:50, 100, 200 mg/kg
Administration:Oral gavage every 3 days for 24 days
Result:Showed inhibition of tumor growth at a rate of 39.1%, 52.7%, and 67.5% in the SKBR3 cell line groups and 27.3%, 39.8%, 54.3% in the MCF-7 cell line groups at the three increasing doses, respectively.
Was well tolerated.

IC 50

HSP90

CONGLOBATIN Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 44)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32265 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Pure Research Chemicals 		13564847951 18019592524 info@purerechem.com China 969 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 thtang@dycnchem.com China 53900 58
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4613 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Lancrix Chemicals 86-21-50817262 sales@lancrix.com China 1502 55

View Lastest Price from CONGLOBATIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Conglobatin pictures 2025-04-28 Conglobatin
72263-05-9
 US $2280.00 / μg 10g TargetMol Chemicals Inc.
  • Conglobatin pictures
  • Conglobatin
    72263-05-9
  • US $2280.00 / μg
  • TargetMol Chemicals Inc.

72263-05-9(CONGLOBATIN)Related Search:

(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione FW-04-806 CONGLOBATIN Conglobatin, >=99% 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (3E,5R,7S,8S,11E,13R,15S,16S)- Conglobactin (3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis[(1,3-oxazol-5-yl)methyl]-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione NGLOBATIN Conglobatin (FW-04-806) 72263-05-9 Antibiotic