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ChemicalBook >> CAS DataBase List >>Lisinopril Dihydrate

Lisinopril Dihydrate

CAS No.
83915-83-7
Chemical Name:
Lisinopril Dihydrate
Synonyms
Lisinopril;Zestfil;renacor;isinopriL;Lisinopril API;(S) Lisinopril;L-154826：MK-521;LISINOPRIL HYDRATE;Lisinopril99%Assay;MK-521 (dihydrate)
CBNumber:
CB3113756
Molecular Formula:
C21H33N3O6
Molecular Weight:
423.51
MDL Number:
MFCD08064198
MOL File:
83915-83-7.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02

Lisinopril Dihydrate Properties

Melting point 148 °C
alpha 25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); 25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate)
refractive index -45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)
storage temp. 2-8°C
solubility H2O: ≥10 mg/mL
pka 2.5, 4.0, 6.7, 10.1(at 25℃)
form solid
color white
Water Solubility H2O: ≥10mg/mL
DMSO: ~6.5mg/mL (with heating and sonicating)
Merck 14,5516
Stability Hygroscopic
CAS DataBase Reference 83915-83-7(CAS DataBase Reference)
NCI Dictionary of Cancer Terms lisinopril
FDA UNII E7199S1YWR
NCI Drug Dictionary lisinopril
ATC code C09AA03
EPA Substance Registry System L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2) (83915-83-7)
UNSPSC Code 41116107
NACRES NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360D-H373
Precautionary statements  P202-P260-P280-P308+P313-P405-P501
Hazard Codes  Xi,Xn
Risk Statements  20/21/22
Safety Statements  22-24/25-36
WGK Germany  3
RTECS  TW3589990
HazardClass  IRRITANT
HS Code  2933995300

Lisinopril Dihydrate price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L6292 Lisinopril ≥98% (HPLC) 83915-83-7 100mg $401 2024-03-01 Buy
Sigma-Aldrich BP695 Lisinopril dihydrate British Pharmacopoeia (BP) Reference Standard 83915-83-7 100MG $262 2024-03-01 Buy
Sigma-Aldrich 1368609 Lisinopril United States Pharmacopeia (USP) Reference Standard 83915-83-7 300mg $436 2024-03-01 Buy
TCI Chemical L0220 Lisinopril Dihydrate >98.0%(T) 83915-83-7 1g $100 2024-03-01 Buy
TCI Chemical L0220 Lisinopril Dihydrate >98.0%(T) 83915-83-7 5g $299 2024-03-01 Buy
Product number Packaging Price Buy
L6292 100mg $401 Buy
BP695 100MG $262 Buy
1368609 300mg $436 Buy
L0220 1g $100 Buy
L0220 5g $299 Buy

Lisinopril Dihydrate Chemical Properties,Uses,Production

Description

Lisinopril is an angiotensin converting enzyme inhibitor structurally related to enalaprilat. It is reportedly useful in the management of hypertension and congestive heart failure.

Chemical Properties

White to Off-White Crystalline Powder

Originator

Merck (USA)

Uses

An orally active angiotensin-converting enzyme (ACE) inhibitor. S,S,S-Isomer of Lisinopril.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Definition

ChEBI: Lisinopril dihydrate is a hydrate. It has a role as an antihypertensive agent. It contains a lisinopril.

brand name

Prinivil (Merck); Zestril (AstraZeneca).

General Description

Lisinopril, 1-[N2-[S-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline dihydrate (Prinivil, Zestril), is alysine derivative of enalaprilat, the active metabolite ofenalapril. Like all ACE inhibitors, it is an active site-directedinhibitor of the enzyme, with the zinc ion used in an effectivebinding interaction at a stoichiometric ratio of 1:1. The pharmacologicaleffects of lisinopril are similar to those of captopriland enalapril.

Biochem/physiol Actions

Angiotensin converting enzyme (ACE) inhibitor.

Clinical Use

Many new ACE inhibitors became available for the treatmentof hypertension following the clinical effectivenessof enalapril. Enalapril is a non–thiol-containing ACE inhibitordevoid of the side effects of rash and loss of thesense of taste characteristic of the thiol-containing compoundcaptopril. With the exception of the phosphoruscontainingfosinopril, these antihypertensive agents havea 2-, like the prototypical drug captopril,are used in the treatment of mild-to-moderate hypertension,either alone or in conjunction with diuretics orcalcium channel blockers.

Veterinary Drugs and Treatments

The principle uses of lisinopril in veterinary medicine at present are as a vasodilator in the treatment of heart failure or hypertension. Recent studies have demonstrated that ACE inhibitors, particularly when used in conjunction with furosemide, do improve the quality of life in dogs with heart failure. It is not clear, however, whether it has any significant effect on survival times. Lisinopril may also be of benefit in treating the effects associated with valvular heart disease (mitral regurgitation) and left to right shunts. It is being explored as adjunctive treatment in chronic renal failure and in protein losing nephropathies.
Lisinopril may have advantages over other ACE inhibitors in that it may be dosed once daily and less expensive. Disadvantages are that it is only available in human labeled dosage forms and there is much less published information on its use (efficacy, safety, dosing) in veterinary species.

Global( 397)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1015 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20235 58
Hangzhou Hyper Chemicals Limited 		+86-0086-57187702781 +8613675893055 info@hyper-chem.com China 295 58
hebei hongtan Biotechnology Co., Ltd 		+852-6619 3215 +86-17731935328 sales03@chemcn.cn China 970 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+86-17396673057 linda@tnjone.com China 1143 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21628 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
Hubei XinRunde Chemical Co., Ltd. 		+8615102730682 bruce@xrdchem.cn CHINA 566 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29858 58

View Lastest Price from Lisinopril Dihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lisinopril Dihydrate pictures 2025-04-25 Lisinopril Dihydrate
83915-83-7
 US $0.00-0.00 / Kg/Drum 1KG 98%-102% HPLC 500KGS WUHAN FORTUNA CHEMICAL CO., LTD
Lisinopril Dihydrate pictures 2025-04-02 Lisinopril Dihydrate
83915-83-7
 US $0.00 / kg 1kg 99% 20tons Shaanxi TNJONE Pharmaceutical Co., Ltd
Lisinopril Dihydrate pictures 2025-03-26 Lisinopril Dihydrate
83915-83-7
 US $412.00 / Kg/Bag 1KG 99 1T Baoji Guokang Bio-Technology Co., Ltd.

Lisinopril Dihydrate Spectrum

Lisinopril Related Compound A (15 mg) ((S)-2-{(3S,8aS)-3-(4-aminobutyl)-1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl}-4-phenylbutanoic acid) (S)-1-[N2-(1-carboxy-3-phenylpropyl)-lysyl-proline dihydrate LIQUID PRED (prednisone),Lisinopril Lisinopril API Lisinopril (Zestril) Lisinopril for system suitability A Lisinopril for peak identification N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline,hydrate (1:2) Lisinopril for system suitability LISINOPRIL-D5 HYDRATE LISINOPRIL HYDRATE (ds)-1-[n2-(1-carboxy-3-phenylpropyl)-l-prolinedihydrate (s)-1-(n(sup2)-(1-carboxy-3-phenylpropyl)-l-lysyl)-l-prolinedihydrate (S)-1-[N2-(1-carboxy-3-phenylpropyl)-lysyl-proline dihydrate, MK-521 L-154826：MK-521 Zestfil (S) -1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-praline dihydrate (2S)-1-[(2S)-6-Amino-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]hexanoyl]pyrrolidine-2-carboxylic acid dihydrate (S)-(-)-1-[N-(1-Carboxy-3-phenylpropyl)-L-lysinyl]-L-proline dihydrate Lisinopril,(S)-1-[N2-(1-carboxy-3-phenylpropyl)-lysyl-proline dihydrate, MK-521 Lisinopril (300 mg) 1-(n(sup2)-(1-carboxy-3-phenylpropyl)-l-lysyl)-,dihydrate,(s)-l-prolin renacor N-[2-[4-[[[(Cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]5-methylpyrazinecarboxamide dihydrate Lisinopril dihydrate USP24,25 EP2000(III) (S) Lisinopril (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]L-proline, Dihydrate, MK-521, Acerbon, Alapril, Carace, Coric, Novatec, Prinil, Prinivil, Tensopril, Vivatec, Zestril (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenyl-propyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid Lisinopril99%Assay LisinoprilC21H31H305*2H20 1-[Nalpha-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl]-L-proline (S)-1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate LISINOPRIL DEHYDRATE (S)-1-{(S)-6-Amino-2-[((S)-1-carboxy-3-phenyl)propylamino]hexanoyl}pyrrolidine-2-carboxylic acid dihydrate LISINOPRIL DIHYDRATE (2S)-1-[(2S)-6-Amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino] hexanoyl] pyrrole-2-carboxylic acid dihydrate Lisinopril 83915-83-7 LISINOPRI (DIHYDRATE) (LMK-521 (DIHYDRATE)) (S)-Lisinopril Dihydrate LisinoprilDihydrate> Lisinopril for peak identification CRS Lisinopril dihydrate CRS Lisinopril for system suitability A CRS MK-521 (dihydrate) isinopriL Lisinopril Dihydrate USP/EP/BP Lisinopril hydrate (MK-521) Lisinopril DihydrateQ: What is Lisinopril Dihydrate Q: What is the CAS Number of Lisinopril Dihydrate Q: What is the storage condition of Lisinopril Dihydrate "Lisinopril for system suitability (Y0001235)"Q: What is "Lisinopril for system suitability (Y0001235)" Q: What is the CAS Number of "Lisinopril for system suitability (Y0001235)" Lisinopril (1368609) Lisinopril Lisinopril diydrate Lisinopril Dihydrate (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-proline Dihydrate Lisinopril Dihydrate, ≥ 98.0% Renopril dihydrate Lisinopril dihydrate in methanol Lisinopril dihydrate, ACE inhibitor Lisinopril dihydrate, 10 mM in DMSO