n-Propylchlorformiat Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT STECHENDEM GERUCH.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger und ?tzender Rauche. Reagiert mit Wasser oder Feuchtigkeit unter Bildung von Chlorwasserstoff. Reagiert sehr heftig mit S?uren, Alkoholen, Aminen, Basen und Oxidationsmitteln. Greift Metall an.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation der D?mpfe und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C tritt sehr schnell eine gesundheitssch?dliche Kontamination der Luft ein.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz ver?tzt die Augen, die Haut und die Atemwege. ?tzend beim Verschlucken. Inhalation des Dampfes kann zu Lungen?dem führen (s. Anm.). Die Auswirkungen treten u.U. verz?gert ein.
LECKAGE
Gefahrenbereich verlassen! Fachmann zu Rate ziehen! Pers?nliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabh?ngigem Atemschutzger?t. NICHT in die Umwelt gelangen lassen. Ausgelaufene Flüssigkeit in abdichtbaren, trockenen Kunststoffbeh?ltern sammeln. Reste mit trockenem Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.
R-S?tze Betriebsanweisung:
R10:Entzündlich.
R23:Giftig beim Einatmen.
R34:Verursacht Ver?tzungen.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Propyl Chloroformate (PCF) is a colorless to yellow liquid, with a pungent odor. It reacts with water and spontaneous decomposes. It is miscible with benzene and ether.
Verwenden
Propyl Chloroformate is used as a dramatizing agent for the determination of morphine, codeine and 6-acetyl morphine in urine and blood using direct aqueous derivatization.
Vorbereitung Methode
Prepared by the reaction of liquid anhydrous n-propyl alcohol
with molar excess of dry, chlorine-free phosgene at low
temperature.
Application
Propyl chloroformate has been used:
as derivatization reagent in quantification of dopamine, serotonin and norepinephrine in human urine by solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry
in the preparation of dipropyl 3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazine-1,2-dicarboxylate
N-propyl chloroformate is an intermediate of the fungicide propamocarb.
synthetische
Synthesis of Propyl chloroformate: Add n-propanol to the phosgene-passing kettle, start stirring, and then pass phosgene through the phosgene flowmeter. The phosgene-passing temperature is about 30 °C, and continue to pass the phosgene for several hours. When the end point is approached, sample and analyze, and stop when the standard is reached. Pass phosgene, cool, and then pass nitrogen to drive away phosgene and hydrogen chloride, destroy phosgene, and sample and analyze it as a product.
Reaction equation: CH3CH2CH2OH+COCl2→ClCOOCH2CH2CH3
Allgemeine Beschreibung
N-propyl chloroformate appears as a colorless liquid. May be decomposed by water. Severely irritates skin and eyes. Very toxic by ingestion, inhalation or skin absorption. Denser than water and vapors heavier than air. Flash point 50°F. Used to make other chemicals.
Air & Water Reaktionen
Highly flammable. Water (moisture in air or soil) reacts with generation of heat and hydrochloric acid.
Reaktivit?t anzeigen
Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air. [EPA, 1998]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
Strongly irritating to eyes and mucous membranes. Poisonous; may be fatal if inhaled, swallowed or absorbed through skin.
Brandgefahr
When heated to decomposition, Propyl chloroformate emits toxic fumes of chlorine containing compounds. Propyl chloroformate is a flammable/combustible material; Propyl chloroformate may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat or fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Runoff from fire control or dilution water may cause pollution. Gradually decomposed by water and alcohol. Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air.
Sicherheitsprofil
Poison by skin contact.
Moderately toxic by ingestion and
inhalation. A corrosive irritant to skin, eyes,
and mucous membranes. Flammable when
exposed to heat or flame, can react
vigorously with oxidizing materials. When
heated to decomposition it emits toxic
fumes of Cl-. Used as a reactive intermediate
to polymerization initiators.
m?gliche Exposition
Propyl chloroformate is used in
organic synthesis; as an intermediate for polymerization
initiators; may have been used as a military poison gas.
Versand/Shipping
UN2740 n-Propyl chloroformate, Hazard class:
6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable
liquid, 8-Corrosive material. Inhalation Hazard Zone B
Inkompatibilit?ten
Propyl chloroformate forms explosive
mixture with air. Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explo-
sions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, water and alcohols.
Reaction with water forms heat and hydrochloric acid.
Attacks some metals and coating in the presence of
moisture.
n-Propylchlorformiat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte