BEPOTASTINE BESILATE
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- CAS-Nr.
- 190786-44-8
- Englisch Name:
- BEPOTASTINE BESILATE
- Synonyma:
- BB;Talion;CS-645;CS-487;Bepreve;TAU 284;Talion (TN);Benzestatine;Betastine besylate;Bepotastine Besylate
- CBNumber:
- CB9810068
- Summenformel:
- C27H31ClN2O6S
- Molgewicht:
- 547.06
- MOL-Datei:
- 190786-44-8.mol
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BEPOTASTINE BESILATE Eigenschaften
- Schmelzpunkt:
- 161-163°
- alpha
- D20 +6.0° (c = 5 in methanol)
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- Aggregatzustand
- Solid
- Farbe
- White to Light Beige
- Optische Aktivit?t
- [α]/D 4.5 to 6.5°, c =1 in methanol
- Stabilit?t:
- Hygroscopic
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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BEPOTASTINE BESILATE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Betotastine was introduced in Japan for the treatment of allergic rhinitis. This
structurally-related derivative of chlorpheniramine and ebastine is prepared by
condensation of optically-resolved 4-[1-(4-chlorophenyl)-1-(2-pyridyl)-methoxy]piperidine
with ethyl 4-bromobutyrate followed by ester hydrolysis. Betotastine is the seventh
marketed non-sedating histamine H
1 antagonist. Its very low sedative side effect is due to
very poor penetration in the central nervous system. Besides its potent and long-acting
activity in models of allergic rhinitis, betotastine was also shown to act as a PAF antagonist and inhibit LTD
4 in tracheal smooth muscle and ileum, IL-5 production by human peripheral
blood mononuclear cells as well as eosinophil infiltration in the airway and peripheral
blood. As a consequence, it is currently being developed against other allergic and
respiratory disorders.
Chemische Eigenschaften
Off-White to Light Beige Solid
Verwenden
Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7
Definition
ChEBI: An organosulfonate salt obtained by combining equimolar amounts of bepotastine and benzenesulfonic acid. A topical, selective and non-sedating histamine (H1) receptor antagonist used for treatment of itching associated with allergic co
junctivitis.
BEPOTASTINE BESILATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
BEPOTASTINE BESILATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 286)Lieferanten
190786-44-8()Verwandte Suche:
- 4-[4-[(4-chlorophenyl)-pyridin-2-ylMethoxy]piperidin-1-yl]butanoic acid benzenesulfonate
- 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, benzenesulfonate (1:1)
- Benzenesulfonate salt
- BEPOTASTINE BESILATE
- (+)-(S)-4-(4-((4-Chlorophenyl)(2-pyridyl)methoxy)piperidino)butyric acid monobenzenesulfonate
- 4-((4-Chlorophenyl)-2-pyridinylmethoxy)- (S)-1-piperidinebutanoic acid monobenzenesulfonate
- Talion (TN)
- Bepotastine Beslilat
- Bepotastine Besylate
- 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (S)-, monobenzenesulfonate
- 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, monobenzenesulfonate
- 4-[4-[(R)-(4-chlorophenyl)-pyridin-2-yl-methoxy]-1-piperidyl]butanoic acid
- (+)-(S)-4-[4-[1-(4-Chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid benzenesulfonate
- bepotastine benzenesulfonate salt
- (S)-4-[4-(4-Chlorophenyl-2-pyridylMethoxy)piperidinyl]butyric Acid Benzenesulfonate
- 4-[(S)-(4-Chlorophenyl)-2-pyridinylMethoxy]-1-piperidinebutanoic Acid Benzenesulfonate
- BB
- Bepotastine Benzenesulfonate
- Bepreve
- Talion
- TAU 284
- Bepotastine Beslilate
- (S)-Bepotastine Besylate
- Bepotastine Besilate (This product is only available in Japan.)
- (S)-4-[4-[(4-Chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl]butanoic Acid Benzenesulfonate
- 4-[4-[(S)-(4-Chlorophenyl)(2-pyridinyl)methoxy]-1-piperidinyl]butanoic Acid Benzenesulfonate
- BEPOTASTINE BESILATE USP/EP/BP
- Betastine besylate
- Bepotastine Besilate (Bepreve)
- Bepotastine BesilateQ: What is
Bepotastine Besilate Q: What is the CAS Number of
Bepotastine Besilate Q: What is the storage condition of
Bepotastine Besilate Q: What are the applications of
Bepotastine Besilate
- Benzestatine
- CS-645
- CS-487
- (S)-4-(4-((4-Chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic acid compound with benzenesulfonic acid (1:1)
- (S)-4-(4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic acid, benzenesulfonic acid
- Bepotastine Besilate, 10 mM in DMSO
- 190786-44-8
- C21H25ClN2O3C6H6O3S
- C27H31ClN2O6S
- 54706
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