Nitroxolin
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Nitroxolin Eigenschaften
- Schmelzpunkt:
- 181-183 °C(lit.)
- Siedepunkt:
- 325.64°C (rough estimate)
- Dichte
- 1.3907 (rough estimate)
- Brechungsindex
- 1.5570 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- alcohol: very slightly soluble
- pka
- 2.55±0.10(Predicted)
- Aggregatzustand
- powder to crystal
- Farbe
- Light yellow to Brown to Dark green
- Merck
- 14,6655
- NIST chemische Informationen
- 8-Hydroxy-5-nitroquinoline(4008-48-4)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T,Xi,Xn | ||
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R-S?tze: | 23/24/25-36/37/38-22/24/25-20/21/22 | ||
S-S?tze: | 26-36-45 | ||
RIDADR | UN 2811 6.1/PG 3 | ||
WGK Germany | 3 | ||
RTECS-Nr. | VC8225000 | ||
Hazard Note | Toxic/Irritant | ||
HazardClass | 6.1 | ||
PackingGroup | III | ||
HS Code | 29334900 | ||
Toxizit?t | LD50 oral in rat: 510mg/kg |
Bildanzeige (GHS) |
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Alarmwort | Achtung | ||||||||||||||||||||||||||||
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Sicherheit |
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Nitroxolin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
Nitroxoline is an 8-hydroxyquinoline that has diverse biological activities, including antibacterial, antiproliferative, and bromodomain interaction-inhibiting properties. Nitroxoline is active against the bacteria E. coli, S. aureus, E. faecalis, K. pneumoniae, and P. mirabilis in vitro (MIC90s = 4, 4, 8, 8, and 8 mg/L, respectively). It also inhibits biofilm formation of certain strains of multidrug-resistant (MDR) A. baumannii and P. aeruginosa, as well as methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE) with minimum biofilm eradication concentration (MBEC) values of 46.9, 1,500, 188, and 125 μM, respectively. Nitroxoline inhibits the growth of human U87 and U251 glioma, A549 lung, and PC3 prostate cancer cells (IC50s = 50, 6, 38, and 23 μg/ml, respectively). In vivo, it reduces tumor growth in a PTEN- and KRAS-driven glioma mouse model when administered at a dose of 80 mg/kg per day. Nitroxoline also inhibits the interaction between the first bromodomain of bromodomain-containing protein 4 (BRD4) with acetylated histone H4 with an IC50 value of 0.98 μM.Chemische Eigenschaften
ochre-yellow to brownish crystalline powderVerwenden
antibacterialDefinition
ChEBI: A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.Weltgesundheitsorganisation (WHO)
Nitroxoline, a urinary antiseptic, was introduced in the mid-1960s. By the early 1970s long-term animal studies revealed the development of cataracts in rats and, although no serious adverse effects had been reported in man, the drug was withdrawn in at least two countries. Preparations containing nitroxoline remain widely available.Nitroxolin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
8-Quinolinol, 5-nitro-, 8-acetate
5-nitroso-8-hydroxyquinoline hydrochloride
8-Ethoxychinolin
5-Nitrosochinolin-8-ol
8-Ethoxy-5-nitroquinoline
2-Amino-4-nitro-phenol
Downstream Produkte
Nitroxolin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 313)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 |
abby@chuanghaibio.com | China | 8808 | 58 |
Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12809 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29730 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29858 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10406 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
Wuhan Chemwish Technology Co., Ltd | 027-67849912 |
sales@chemwish.com | CHINA | 10821 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49732 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9636 | 58 |
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21142 | 58 |
4008-48-4(Nitroxolin)Verwandte Suche:
5-Nitrochinolin
4-Nitrobenzoes?ure
Quinclorac
Isochinolin
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
3'-Nitroacetophenon
8-Hydroxychinolin
2-Methylchinolin-8-ol
Chinhydron
Ethoxychin
5,7-Dihydroxy-2-phenyl-4H-benzo[b]pyran-4-on
Quinoline Yellow
Stickstoffdioxid
Nitromethan
Nitrobenzol
TRITON
5-Nitrosochinolin-8-ol
Chinolin
- 5-NITRO-8-QUINOLINE
- 5-NITRO-8-QUINOLINOL
- NOTROXOLINE
- NITROXOLINE
- 5-Nitro-8-oxychinoline
- 5-Nitro-8-oxyquinoline
- 5-Nitro-8-quinolinol Nitroxoline
- 8-hydroxy-5-nitrozo-quinoline
- Enterocol
- Uritrol
- Urocoli
- 5-Hydroxy-8-nitroquinoline
- 5-(Hydroxyl[oxido]aMino)-8-hydroxyquinoline
- NSC 74947
- NSC 74948
- 5-Nitro 8-OH-Quinoline
- 8-Hydroxy-5-nitroquinoline 97%
- Nitroxoline (5-Nitro-8-quinolinol
- N-(8-hydroxyquinolin-5-yl)azinic acid
- 5-nitro-8-quinolino
- 5-Nitroks
- 5-Nitro-quinolin-8-ol
- 5-nitrox
- 5-Nitroxine
- 5nok
- 5-NOK
- 8-Quinolinol, 5-nitro-
- A-82
- bas58
- Nibiol
- Nitrohydroxyquinoline
- Noxibiol
- Noxin
- Quinolin-8-ol, 5-nitro-
- 8-Hydroxy-5-nitroquinoline,96%
- 5-Nitrooxine
- Nitrooxine
- 5-nitro-8-hydroxyquinolin
- 8-HYDROXY-5-NITROQUINOLINEHYPOXIA-SELECTIVE ANTITUMOR AGENTS ANTI-BACTERIAL AND ANTI-FUNGAL AGENTS
- 8-Hydroxy-5-nitroquinoline>
- Nitroxoline (8-Hydroxy-5-nitroquinoline)
- Nitroxoline ISO 9001:2015 REACH
- 8-HYDROXY-5-NITROQUINOLINE
- 5-NITRO-8-HYDROXYQUINOLINE
- Nitroxolin
- Niroxoline
- Niroxoline in acetonitrile
- Nitroxoline, 10 mM in DMSO
- 4008-48-4
- C9H6N2O3
- Heterocyclic Building Blocks
- Building Blocks
- Hydroxyquinolines
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- ENTEROCOL
- pesticide intermediates
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