4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Diphemanil is a quaternary ammonium anticholinergic agent. It induces relaxation of isolated guinea pig trachea strips precontracted with methacholine (EC₅₀ = 0.12 nM). Diphemanil reverses increases in lung resistance and decreases in dynamic lung compliance induced by the non-selective acetylcholine receptor agonist carbachol (carbamoylcholine; ) in vagotomized cats (ED₅₀s = 17.5 and 19.3 μg/kg, respectively). It reduces salivation induced by the muscarinic acetylcholine receptor agonist pilocarpine in mice when administered subcutaneously at doses ranging from 1.25 to 10 mg/kg.

Verwenden

Bronchodilatator;Anticholinergic

Definition

ChEBI: The alkene resulting from the formal Wittig olefination of benzophenone and 1,1-dimethyl-4-bromopiperidinium methylsulfate. A quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stoma h acids, saliva and sweat, It is used topically in the treatment of hyperhidorsis (excessive sweating).

Allgemeine Beschreibung

Diphemanil methylsulfate,4-(diphenylmethylene)-1,1-dimethylpiperidiniummethylsulfate (Prantal), or diphemanil methylsulfate is apotent cholinergic blocking agent. In the usual dosagerange, it acts as an effective parasympatholytic by blockingnerve impulses at the parasympathetic ganglia, but it doesnot invoke a sympathetic ganglionic blockade. It is claimedto be highly specific in its action on those innervations thatactivate gastric secretion and GI motility. Although thisdrug can produce atropine-like side effects, they rarelyoccur at recommended doses. The highly specific nature ofits action on gastric functions makes the drug useful inthe treatment of peptic ulcer, and its lack of atropine-likeeffects makes its use much less distressing than other antispasmodicdrugs. In addition to its action in decreasinggastric hypermotility, diphemanil methylsulfate is valuablein hyperhidrosis in low doses (50 mg twice daily) or topically.The drug is not well absorbed from the GI tract,particularly in the presence of food, and should be administeredbetween meals. The methylsulfate salt was chosen asthe best, because the chloride is hygroscopic and the bromideand iodide ions have exhibited toxic manifestations inclinical use.

4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2526	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32080	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34553	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15354	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58

62-97-5(4-(Diphenylmethylen)-1,1-dimethyl-piperidinium-methyl-sulfat)Verwandte Suche:

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• nivelona
• p-(alpha-phenylbenzylidene)-1,1-dimethylpiperidiniummethylsulfate
• prantal
• prantalmethylsulfate
• vagophemanil
• vagophemanilmethylsulfate
• variton
• DIPHEMANIL METHYLSULFATE (500 MG) DISCON-TINUED
• 4-(diphenylmethylene)-1,1-dimethyl-piperidiniumethylsulfate
• n,n-dimethyl-4-piperidylidene-1,1-diphenylmethanemethylsulfate
• Diphemanil mesylate
• diphemanil metilsulfate
• Diphenmanil methosulfate
• Talpran
• 4-benzhydrylidene-1,1-dimethyl-piperidin-1-ium
• 4-benzhydrylidene-1,1-dimethylpiperidin-1-ium
• Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate
• Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)
• 4-(diphenylmethylene)-1,1-dimethylpiperidiniummethylsulfate
• demotil
• diphemanil
• diphemanilmethylsulfate
• diphenatil
• diphenmanilmethylsulfate
• diphenmethanil
• diphenmethanilmethylsulfate
• DIPHEMANIL METHYLSULFAT
• 4-(Diphenylmethylene)-1,1-dimethylpiperidin-1-ium Methyl Sulfate
• Diphemanil Methylsulfate USP/EP/BP
• iphemanilmethylsulfate
• 62-97-5
• 62-97-6
• C20H24NCH3O4S
• Other APIs