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Semaglutide

Semaglutide Struktur
910463-68-2
CAS-Nr.
910463-68-2
Englisch Name:
Semaglutide
Synonyma:
semaglutide;Semaglutide impurity;Sermaglutide USP/EP/BP;Sermaglutide CAS 910463 68 2;OG217SC;Ozempic;Somaroutin;semgalutide;Somaglutide;Somarlutide
CBNumber:
CB93069423
Summenformel:
C187H291N45O59
Molgewicht:
4113.57754
MOL-Datei:
910463-68-2.mol

Semaglutide Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
DMSO:3mg/mL (0.73 mM)
Aggregatzustand
Solid
Farbe
White to off-white
InChIKey
DLSWIYLPEUIQAV-CCUURXOWSA-N
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Semaglutide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Semaglutide(910463-68-2) is an anti-diabetic medication that is sold under brand names such as Ozempic, Wegovy, and Rybelsus. It is used to treat type 2 diabetes and manage chronic weight. The drug functions similar to human glucagon-like peptide-1 (GLP-1) by increasing insulin secretion, which leads to improved sugar metabolism. It is distributed as a metered subcutaneous injection in a prefilled pen, or as an oral form. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week injection is sufficient.

Verwenden

Semaglutide is used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity. It also works by slowing the movement of food through the stomach and may decrease appetite and cause weight loss. There have been no published reports of hepatotoxicity attributed to semaglutide therapy.

Mechanism of action

Semaglutide is a glucagon-like peptide-1 receptor agonist. It increases the production of insulin, a hormone that lowers the blood sugar level. It also appears to enhance growth of β cells in the pancreas, which are the sites of insulin production. It also inhibits glucagon, which is a hormone that increases blood sugar. It additionally reduces food intake by lowering appetite and slows down digestion in the stomach. In this way it reduces body fat.

Pharmakokinetik

Median tmax,semaglutide was 1.5 hours for both water volumes with a range of 0.5-3.0 hours for 50 mL and a range of 0.5-4.0 hours for 240 mL. AUC0-24h,semaglutide and Cmax,semaglutide were approximately 70% higher when dosed with 50 versus 240 mL water[2].

Nebenwirkungen

Some common side effects of Semaglutide include: nausea, vomiting, diarrhea, abdominal pain, and constipation may occur.
Less common but serious side effects of Semaglutide include: kidney problems, diabetic retinopathy, allergic reactions, low blood sugar, and pancreatitis.
In people with heart problems, it can cause damage to the back of the eye (retinopathy). If you experience any of these serious side effects, contact your healthcare provider immediately.
www.mayoclinic.org

Stoffwechsel

Intact semaglutide was the primary component circulating in plasma for humans and both nonclinical species, accounting for 69–83% of the total amount of semaglutide-related material, and was metabolised prior to excretion. Recovery of excreted radioactivity was 75.1% in humans, 72.1% in rats and 58.2% in monkeys. Urine and faeces were shown to be important routes of excretion, with urine as the primary route in both humans and animals[1]. Semaglutide was metabolised through proteolytic cleavage of the peptide backbone and sequential beta-oxidation of the fatty acid sidechain, and metabolism was not confined to specific organs. Intact semaglutide in urine accounted for 3.1% of the administered dose in humans and less than 1% in rats; it was not detected in urine in monkeys.

Vorsichtsma?nahmen

The FDA recommends Wegovy for weight loss if you meet one of the following criteria: Have a body mass index (BMI) of 27kg/m2 or greater and at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or high cholesterol; Have a BMI of 30kg/m2 or greater.
Avoid semaglutide if you have: History of medullary thyroid cancer; History of gallbladder disease; History of pancreatitis; Multiple endocrine neoplasia syndrome type 2 (MEN2).

Semaglutide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Semaglutide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 475)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Yuanao Technology CO Ltd
+86-15377628618 +86-15377628618
info@yuanaotech.com China 6 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2524 58
Cellmano Biotech Limited
0551-65326643 18156095617
info@cellmano.com China 1000 58
Alpha Biopharmaceuticals Co., Ltd
+86-15542445688
sales@alabiochem.com China 888 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15361 58
Senova Technology Co. Ltd.
+86-0755-86703119 +8618503098836
info@senovatech.com China 351 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
Wuhan Cell Pharmaceutical Co., Ltd
+86-13129979210 +86-13129979210
sales@cellwh.com China 376 58
Sigma Audley
+86-15937194204 +86-18126314766
nova@sh-teruiop.com China 493 58
Dorne Chemical Technology co. LTD
+86-86-13583358881 +8618560316533
Ethan@dornechem.com China 3106 58

910463-68-2()Verwandte Suche:


  • Sermaglutide
  • Semaglutide (H-7894.0001)
  • semaglutide
  • Semaglutide impurity
  • Sermaglutide USP/EP/BP
  • Sermaglutide CAS 910463 68 2
  • semgalutide
  • Semaglutide Injection
  • Somalutamide
  • Somaglutide sodium salt
  • Somaroutin
  • Somaglutide
  • Semaglutide powder
  • Semaglutide Tirzepatide
  • GLP-1 analogue
  • Semaglutide free base
  • Semaglutide(sodium salt)
  • Semaglutide
  • Somarlutide
  • hot sale semagluti-de
  • NNC 0113-0217
  • NNC-0113-0217
  • NNC0113-0217
  • OG217SC
  • Ozempic
  • Semaglutide peptide
  • semaglutide pill
  • semaglutide premix
  • Semaglutide 99% White powder High Quality semaglutide weight loss
  • Semaglutide peptide weight loss peptide
  • Simeglutide
  • 910463-68-2
  • 920463-68-2
  • GLP
  • PP
  • APIs
  • API
  • 910463-68-2
  • GLP-1
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