Tetracosactid
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- CAS-Nr.
- 16960-16-0
- Bezeichnung:
- Tetracosactid
- Englisch Name:
- Tetracosactide acetate
- Synonyma:
- TETRACOSACTIDE;synacthen;cortrosyn;tetracosactrin;Tetracosactide CRS;Tetracosactide acetate;SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO;acth-z;C06926;ba30920
- CBNumber:
- CB1325409
- Summenformel:
- C136H210N40O31S
- Molgewicht:
- 2933.44
- MOL-Datei:
- 16960-16-0.mol
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Tetracosactid Eigenschaften
- Dichte
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- L?slichkeit
- Sparingly soluble in water.
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- Wasserl?slichkeit
- Soluble in water
- Sequenz
- H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
- Stabilit?t:
- Hygroscopic
- InChIKey
- ZOEFCCMDUURGSE-SQKVDDBVSA-N
- CAS Datenbank
- 16960-16-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P272 |
Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P285 |
Bei unzureichender Belüftung Atemschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P304+P341 |
BEI EINATMEN: Bei Atembeschwerden an die frische Luft bringen und in einer Position
ruhigstellen, die das Atmen erleichtert |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P321 |
Besondere Behandlung |
| P333+P313 |
Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P342+P311 |
Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Tetracosactid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cosyntropin (Tetracosactide acetate) is a synthetic polypeptide that consists of amino acid residues 1 through 24 of
human ACTH, but that has the full biological activity of its parent. Because it is of synthetic
origin, it is less allergenic than ACTH of natural origin. Cosyntropin is used as a diagnostic
agent in the screening of patients suspected of having adrenocortical insufficiency. Normally,
parenteral administration of cosyntropin acts rapidly on the adrenal cortex to effect release of
plasma hydrocortisone; when performing the test, the hydrocortisone levels are compared to a
control blood sample taken earlier.
Chemische Eigenschaften
White or yellow, amorphous powder.
Definition
ChEBI: A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of cort
costeroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.
Indications
Cosyntropin (Cortrosyn) is a polypeptide that consists
solely of the first 24 amino acids of corticotropin. It appears
to offer an advantage over the naturally occurring
hormone in that it has a longer duration of action and
lacks the antigenic portion of corticotropin. Although
the short cosyntropin test is recognized as a valid
screening test to assess adrenocortical insufficiency, the
overnight metyrapone test or insulin hypoglycemia test
may prove more sensitive.
Allgemeine Beschreibung
Cosyntropin (Cortrosyn) is a syntheticpeptide containing the first 24 amino acids of natural corticotropin.Cosyntropin is used as a diagnostic agent to testfor adrenal cortical deficiency. Plasma hydrocortisone concentrationis determined before and 30 minutes after theadministration of 250 g of cosyntropin. Most normal responses result in an approximate doubling of the basalhydrocortisone concentration in 30 to 60 minutes. If the responseis not normal, adrenal insufficiency is indicated.Such adrenal insufficiency could be a result of either adrenalor pituitary malfunction, and further testing is requiredto distinguish between the two. Cosyntropin (250 μg infusedwithin 4–8 hours) or corticotropin (80–120 U/day for3–4 days) is administered. Patients with functional adrenaltissue should respond to this dosage. Patients who respondaccordingly are suspected of hypopituitarism, and the diagnosiscan be confirmed by other tests for pituitary function.Patients who have Addison disease, however, show little orno response.
Nebenwirkungen
Common side effects of Tetracosactide acetate may include:
an allergic reaction (hives; difficult breathing; swelling of your face, lips, tongue, or throat);
fast or slow heartbeats;
increased blood pressure;
rash;
swelling in your hands or feet.
Tetracosactid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tetracosactid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 273)Lieferanten
16960-16-0(Tetracosactid)Verwandte Suche:
- L-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO
- cosyntropin
- H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG PRO-VAL-LYS-VAL-TYR-PRO-OH TETRACOSACTIDE (HUMAN, BOVINE, MOUSE, OVINE, PORCINE, RABBIT, RAT)
- H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-OH
- SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO HUMAN
- TETRACOSACTIDE (HUMAN)
- SYSMEHFRWGKPVGKKRRPVKVYP
- acth-alpha(1-24)
- acthalpha(1-24)
- actholain
- acth-z
- adrenocorticotropichormone1-24
- adrenocorticotropin(1-24)
- alpha(1-24)acth
- alpha(1-24)-acth
- alpha(1-24)-corticotropin
- alpha(sup1-24)-corticotropin
- ba30920
- ba36716
- beta(1-24)acth
- beta(1-24)-acth
- beta(1-24)-corticotropin
- beta(1-24)-tetracosactide
- beta(sup1-24)-corticotropin
- beta-corticotrophin-(1-24)-tetracosapeptide
- corticotropin-(1-24)
- cortrophins
- cortrosinta
- enylalanyl-l-arginyl-l-tryptophylglycyl-l-l///
- l-proline,l-seryl-l-tyrosyl-l-seryl-l-methionyl-l-glutamyl-l-alpha-histidyl-ph
- Tetracosactide, Cosyntropin, Tetracosactrin
- Adrenocorticotropic hormone fragment 1-24 human (ACTH)
- nuvacthendepot
- porcineacth(1-24)
- synecthen
- tetracosactid
- tetracosapeptide
- Fam-ACTH (1-24), human
- α1-24-Adrenocorticotropic-d4 Hormone
- α1-24-Adrenocorticotropic Hormone
- Cosyntropin Acetate
- 1-icosyl-8-methyl-8-azabicyclo[3.2.1]octan-3-ol
- Tetracosactide(1-24)/ACTH (1-24) Acetate
- ADRENOCORTICOTROPIC HORMONE FRAGMENT1-24 HUMAN
- adrenocorticotropic hormone fragment 1-24 human, rat
- ACTH (1-24), HUMAN
- ACTH (1-24) (HUMAN, BOVINE, MOUSE, OVINE, PORCINE, RABBIT, RAT)
- ACTH (1-24)
- ACTH (HUMAN, 1-24)
- ADRENOCORTICOTROPIC HORMONE HUMAN FRAGMENT 1-24
- ADRENOCORTICOTROPIC HORMONE (HUMAN,1-24)
- ADRENOCORTICOTROPIC HORMONE FRAGMENT 1-24
- ADRENOCORTICOTROPIC HORMONE 1-24, HUMAN
- Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
- α1-24-Corticotropin
- H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH acetate salt
- Cosyntrophin
- tetracosactrde
